Zoonotic Diseases, infections that can be transmitted between animals and humans, not only pose significant threats to public health but also have profound economic implications. The interconnectedness of global trade and travel means that the economic consequences of zoonotic outbreaks extend far beyond the immediate health impact. The livestock industry, in particular, is vulnerable to Zoonotic Diseases, with outbreaks affecting production, trade, and food security. The economic burden of Zoonotic Diseases is multifaceted. Direct costs include expenses related to healthcare, treatment, and control measures, while indirect costs encompass productivity losses, trade restrictions, and the economic downturn associated with public fear and reduced consumer confidence. In addition, Zoonotic Diseases can impact tourism, disrupt supply chains, and strain healthcare systems, creating a ripple effect that resonates across diverse sectors. Addressing the economic impact of Zoonotic Diseases requires a comprehensive One Health approach. This approach recognizes the interconnectedness of human, animal, and environmental health and emphasizes collaboration between public health officials, veterinarians, environmental scientists, and policymakers. By integrating surveillance systems, sharing data across sectors, and implementing preventive measures at the human-animal-environment interface, nations can work together to mitigate the economic consequences of zoonotic outbreaks.