Keynote Presentation
New technologies using blood immune cells in inform on human disease status
John J Miles, James Cook University, Australia
The human immune system is a hugely complex network of cell types relentlessly communicating on host health through direct recognition and secreted compounds. We have recently found that listening to this immune cell “chatter” through phenotyping or molecular typing can inform pathology in rapid time using high-dimensional analysis and [....]
Flavodoxins as drug targets. Novel Helicobacter pylori specific antimicrobials
Javier Sancho, University of Zaragoza, Spain
Antimicrobial resistance constitutes a global health challenge that must be met by developing novel therapeutic tools. Flavodoxins are small bacterial proteins that participate in many key metabolic pathways and are promising targets for the development of novel antimicrobials against pathogenic bacteria. The main structural and biochemical feature [....]
Non-typhoidal Salmonella: Why Should We Care?
Manal Mohammed, University of Westminster, UK
Non-typhoidal Salmonella (NTS) Dublin has adapted to cause invasive illness in humans. There is no vaccine against iNTS and disease management is further complicated by the emergence of multidrug resistant (MDR) strains. It is estimated that invasive non-typhoidal Salmonella (iNTS) serovars cause over 680,000 human deaths per year. We apply next ge [....]
Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for schizophrenia
Segundo Mesa Castillo, Psychiatric Hospital of Havana, Cuba
There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus [1]. The current available technology doesn't allow observing what is happening at cell [....]
Medical ozone therapy as the effective treatment for Ebola and AIDs
Sorush Niknamian, University of Cambridge, USA
Ebola is a virus. It incubates for 2 to 21 days and then roars to life to induce death. Ebola first tricks the immune system into thinking nothing is there. The virus enters many different types of cells in the human body. It multiplies extremely rapidly, emerges from the cell to infect yet more. Interestingly, much of the damage induced by the inf [....]
Zoonotic Tuberculosis: Characterization of Antibody Responses in Various Host Species for Improved Serodiagnosis
Konstantin Lyashchenko, Chembio Diagnostic Systems, Inc., USA
Bovine tuberculosis (bTB) has a broad range of mammalian host species including various livestock and wildlife animals. Ante-mortem testing for bTB traditionally relies on cell-mediated immune responses, such as tuberculin skin test reactions or in vitro interferon-gamma release. However, serological methods using novel antigens and advanced assay [....]
Combined Tuberculosis/HIV infection in Russia: Current status and perspectives
Erzheny Tsybikova, Federal Research Institute for Health Organization, Russia
Objective: Epidemiology of combined TB/HIV infection in the Russian Federation over the past 10 years (2009-2018). Materials and methods: retrospective analysis of statistical data received from the reporting forms of the ROSSTAT and MoH of Russia for the period (2009-2018). For the analysis, cartographic and correlation analyses were used. R [....]
Potential for spread of Leishmania tropica in southern Europe by local sand flies
Petr Volf, Charles University, Czech Republic
Various Leishmania species constitute an important global health problem with millions of people affected. Leishmania tropica is the causative agent of cutaneous leishmaniases (CL) in the Old World, occurring in many countries of Asia and Africa. Currently, a great concern is posed by outbreaks of CL in the Middle East, connected with people displa [....]
Sepsis as a metabolic adaptation failure
Claude Libert, Center for Inflammation Research, Belgium
Sepsis is a most deadly unmet medical need. It hits 30 million people yearly, leading to 8 million deaths, amongst which 3 million children. Usually, sepsis starts with a serious (bacterial) infection that spreads and triggers many systems of the host, including inflammation, immunity, coagulation, complement, but also thermoregulation, circadian r [....]