Antimicrobial resistance constitutes a global health challenge that must be met by developing novel therapeutic tools. Flavodoxins are small bacterial proteins that participate in many key metabolic pathways and are promising targets for the development of novel antimicrobials against pathogenic bacteria. The main structural and biochemical feature [....]
Non-typhoidal Salmonella (NTS) Dublin has adapted to cause invasive illness in humans. There is no vaccine against iNTS and disease management is further complicated by the emergence of multidrug resistant (MDR) strains. It is estimated that invasive non-typhoidal Salmonella (iNTS) serovars cause over 680,000 human deaths per year. We apply next ge [....]
There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus . The current available technology doesn't allow observing what is happening at cell [....]
Ebola is a virus. It incubates for 2 to 21 days and then roars to life to induce death. Ebola first tricks the immune system into thinking nothing is there. The virus enters many different types of cells in the human body. It multiplies extremely rapidly, emerges from the cell to infect yet more. Interestingly, much of the damage induced by the inf [....]
Objective: Epidemiology of combined TB/HIV infection in the Russian Federation over the past 10 years (2009-2018).
Materials and methods: retrospective analysis of statistical data received from the reporting forms of the ROSSTAT and MoH of Russia for the period (2009-2018). For the analysis, cartographic and correlation analyses were used.
Various Leishmania species constitute an important global health problem with millions of people affected. Leishmania tropica is the causative agent of cutaneous leishmaniases (CL) in the Old World, occurring in many countries of Asia and Africa. Currently, a great concern is posed by outbreaks of CL in the Middle East, connected with people displa [....]
Sepsis is a most deadly unmet medical need. It hits 30 million people yearly, leading to 8 million deaths, amongst which 3 million children. Usually, sepsis starts with a serious (bacterial) infection that spreads and triggers many systems of the host, including inflammation, immunity, coagulation, complement, but also thermoregulation, circadian r [....]
The human immune system is a hugely complex network of cell types relentlessly communicating on host health through direct recognition and secreted compounds. We have recently found that listening to this immune cell “chatter” through phenotyping or molecular typing can inform pathology in rapid time using high-dimensional analysis and [....]
The implementation in our institution, Regional Reference Center for the study of Tropical Diseases, of the Institutional Committee for the Care and Use of Laboratory Animals (IACUC), meant a change in the institutional approach in research with laboratory animals due to the need to respect the welfare of animals in the study of preclinical researc [....]
The chemistry of the heterocycles constitutes one of the research themes very studied and developed in organic synthesis. Many heterocyclic derivatives are found to exhibit various biochemical, agro-chemical and electrochemical activities .
In continuation of our research interest in heterocyclic compounds and those precursors, we report in t [....]
Decompensated liver disease is a huge burden on countries that suffer from high rates of chronic hepatitis or alcoholism, also recently NASH entered in the strong contenders after the regression of chronic HCV with oral direct antivirals. Liver decompensation in the form of hepatocellular or vascular decompensation carries the risk of disturbed imm [....]
Bacterial infections are worldwide problem health. Bacterial infections are described as the proliferation of harmful bacteria on or inside the body. There is a long list of infections among pneumonia, meningitis, sexually transmitted, bacterial skin infections, respiratory infections or nosocomial infections. Nosocomial infections or healthcare-as [....]
Infections caused by antibiotic-resistant ESKAPE group microorganisms possess high risk to patients' lives, because treatment is limited to few therapeutic options. The resistance mechanisms are: production of Extended Spectrum Lactamases (BLEE), Carbapenemes type MBL, enzymatic production of aminoglycoside resistance (HLRA), resistance t [....]
Pseudomonas exotoxin A (ETA) is the most potent virulence determinant produced by Pseudomonas aeruginosa which is one of the foremost causes of life-threatening nosocomial infections. The ETA catalyzes the ADP-ribosylation of eukaryotic elongation factor-2 halting protein synthesis and leading to mammalian cell death. Engineered single-chain antibo [....]
Pseudomonas aeruginosa could be infected almost body tissues and is known to cause skin infections, endocarditis, pneumonia and bacteremia, sepsis diseases.
National Culture Collection for Pathogens (NCCP) in Korea is to distribute pathogen resources and provide their various information of quality assured to use to disease diagnostic researches [....]
The National Culture Collection for Pathogens (NCCP) is the biobank of the Korea Centers for Disease Control & Prevention and has a variety of clinically isolated pathogens from Korea. The NCCP strives to contribute to healthcare industries with its characterized strains. The informative characteristics of each resource are used to research, [....]
Acute lower respiratory tract infections are a major cause of morbidity and hospital admissions. This study aimed to determine the viral etiology of these infections among the patients of different age groups in Bulgaria during the period October 2016-September 2019. Nasopharyngeal specimens were collected from patients with bronchiolitis, pneumoni [....]
The Middle East and North Africa (MENA) new HIV cases show the highest increase among all regions in the world. Even though Egypt has a low prevalence among the general population (< 0.02%), a national HIV epidemic occurs in certain population risk groups. The current study was conducted to asses clinical and immunological disease progression; f [....]
Mutations in the pncA gene are the major cause of resistance to pyrazinamide (PZA), but there are alternative mechanisms that also provide resistance. The objective of the study was to standardize the pncA gene complementation technique in Mycobacterium tuberculosis H37Rv pncA-knockout to evaluate the effect of mutations in the pncA gene, in a scen [....]
Objective: There are a large number of patients who present with chest symptoms of short duration at secondary and tertiary care centers with a background history of anti-tubercular therapy in the past. The literature regarding the evaluation and management of such patients is scarce. Therefore a study was planned with the aim of to assess the sens [....]
Globally, scabies causes substantial morbidity and mortality. In the tropics, scabies frequently promotes opportunistic bacterial infections, leading to cellulitis/necrotizing fasciitis, bacteraemia, kidney disease and/or rheumatic heart disease. With no vaccine, diagnostic tools and limited treatment options, scabies is considered neglected by WHO [....]
Gonococcal infection belongs to the most common sexually transmitted infections. Due to the developing antimicrobial resistance, in particular, resistance to fluoroquinolones and 3rd generation cephalosporins, Neisseria gonorrhoeae is considered to be a high priority pathogen according to the WHO list.
In this work, we analyzed 270 N. gonorrhoea [....]
Bacterial pathogens have been used during quality control while developing medicine, cosmetics, and feed in healthcare and industrial fields worldwide. Some countries including America, China, and Japan, as well as a few from Europe, have their own pharmacopoeias and they approve medical supplies that have undergone quality assurance based on steri [....]
The World Health Organization has placed patient safety as a high priority on the agenda, being the first challenge to reduce healthcare-associated infections (HAIs). HAIs are considered undesirable events arising out of the process of health care and represent a major concern for global public health. These infections prolong the length of hospita [....]
Zoonotic diseases have always been of concern to humans, one of the most common is toxoplasmosis, a worldwide disease caused by the etiological agent Toxoplasma gondii (Carrada, 2005), which affects birds, mammals and man, Basso and Venturini (2009) mention that: “The infection has a variable clinical presentation according to the affect [....]
Background: Meningitis means the membranes that cover the brain, spinal cord, and the intervening cerebrospinal fluid becomes inflamed as a result of infection of cerebrospinal fluid by a variety of infectious agents. Acute meningitis is caused by a variety of infectious agents. The most serious form is caused by pyogenic bacteria, [....]
Aim: Diabetic nephropathy (DN) is considered as one of the diabetic complications affecting up to 40% of patients with type 1 or type 2 diabetes. In clinical practice, the frequently used markers of renal disease and progression are serum creatinine, estimated glomerular filtration rate (eGFR) and albuminuria. The aim of this study is to [....]
Human adenovirus (HAdV) causes upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. A retrospective study was conducted on children admitted with acute respiratory infections with PCR positive adeno virus at Institute of Child Health, Kolkata from [....]
Administration of prophylactic antibiotics is a standard practice before cardiac surgeries. The previously recommended prophylactic antibiotics for cardiac surgeries were Cefuroxime and Levofloxacin. Patients were monitored up to three months post-surgery ascertained through routine infection control surveillance using the National Healthcare Safet [....]