Title : Gut microbiome and extrapulmonary forms of tuberculosis
Abstract:
The scientific world believes that microbial correction of microbiota in patients with extrapulmonary forms, including tuberculosis of bones and joints, is important not only for studying the state of health. Now scientists are sure that microbes are important for the treatment of diseases. How can intestinal microbiota dysbiosis modulate the body's susceptibility to Mycobacterium tuberculosis? The main material of the study was 100 patients, of which 60 (60.0%) patients with complicated tuberculous spondylitis made up group 1; 40 (40.0%) patients with nonspecific spondylitis made up group 2. The examined patients were determined to have disorders of the motor function of the gastrointestinal tract in complicated tuberculous spondylitis with dysfunction of the spinal cord, i.e. in the pre- and postoperative period, localization of the tuberculous process in the segment of the spine affected by tuberculosis, risk factors for variants of disorders of the motor function of the gastrointestinal tract. The majority were people of working age from 21 to 60 years old - 64.1% (n = 59). The average age was 37.2 ± 1.2 years. Of the examined patients, there were men; in group 1 there were 32 (53.3%) people; in group 2 - 22 (55.0%) people; women; in group 1 - 28 (52.1%) people; in group 2 - 18 (47.8%) people. Objectives. To summarize the results of studies of the intestinal microbiome in patients with tuberculosis of bones and joints. Taxonomic diversity indices indicated differences in the structure of microbial communities of healthy bones and joints and patients with tuberculosis. The composition of the microbiota of healthy bones and joints was distinguished by taxonomic diversity and was represented by gram-positive and gram-negative bacteria with fairly close metabolic potential. The microbiota of bones and joints examined for tuberculosis consisted of 99.9% Mycobacterium tuberculosis.
