Title : Platelet to Lymphocyte Ratio (PLR) value a good indicator, to predict mortality in sepsis
Abstract:
Background:
Sepsis is a life-threatening condition that occur due to an uncontrolled immune response to infectious agents in the body, potentially leading to functional failure in various organs. It is critical to identify patients at high risk of mortality due to sepsis and shock as early as possible to improve patient outcomes. Platelet to lymphocyte ratio (PLR) is a potential prognostic entity that can predict patients with sepsis who are at high risk of mortality.
Objective:
Determine the relationship between peripheral blood Platelet to lymphocyte ratio (PLR) and mortality in patients with sepsis through a systemic review and meta-analysis.
Methods:
A comprehensive search was performed across 3 databases: PubMed, Scopus and Web of science on December 5, 2024, to identify studies conducted to identify the potential association between PLR and mortality in patients with sepsis. As different studies used different diagnostic criteria to diagnose sepsis, we used Standard mean difference (SMD) with 95% CI was used to report the differences in PLR values among these studies. Subgroup analysis was also performed based on various factors. Cochrane's Q test was used to assess heterogeneity. Egger’s test value (0.031) and asymmetry in forest plot indicated the potential publication bias contributing to heterogeneity. A random effect model was used to generalize the results.
Results:
26 studies containing a total of 9012 patients including adults and children were considered. Both Retrospective (17) and Prospective (9) studies were included.
Conclusion:
Elevated PLR in patients with sepsis associated with high mortality irrespective of age, race and in-patient or out-patient setting.
