Title : A rare case report: Hepatitis due to Chlamydia trachomatis infection in a 50 year old male patient
Eszter Tothne Karip, Maitland Hospital, Australia
We would like to present a rare case of hepatitis with Fitz-Hugh-Curtis syndrome caused by Chlamydia Trachomatis infection in a middle-aged man. Perihepatitis or Fitz-Hugh-Curtis syndrome is a well-known complication of Pelvic Inflammatory Disease in female patients, but it ha [....] » Read More


Title : Phenotypic characterisation of non tuberculous mycobacterium species isolated from clinical specimens
Anant Marathe, Parul Institute of Medical Sciences and Research, Parul University, India
Background: Non tuberculous bacteria (NTM) are increasingly recognised cause of pulmonary as well as extrapulmonary infection worldwide. This rising prevalence of NTM, particularly rapidly growing mycobacteria along with their inherent and acquired drug resistance, and species-sp [....] » Read More
Title : Praziquantel for the treatment of preschool-aged children with schistosomiasis: Results of an RCT
Susannah Colt, Warren Alpert Medical School of Brown University, United States
Background: Optimal dosing of praziquantel for schistosomiasis for children younger than 5 years is not established and some studies suggest this age group might need a higher dosing per kilogram. Our aim was to assess the safety and efficacy of 80 mg/kg of praziquantel tabl [....] » Read More
Title : Progress in diagnosis and treatment in elderly patients with tuberculosis obstructive pulmonary disease
Wenli Cao, Beijing Geriatric Hospital, China
The obstructive pulmonary disease tuberculosis B (tuberculosis obstructive pulmonary called TOPD disease) in elderly patients with tuberculosis is a common and early prevention and treatment, the latter to irreversible persistent airflow limitation and accompanied by chronic airw [....] » Read More
Title : Exploring the health-seeking journeys of individuals affected by leprosy: Lived experiences in selected urban rehabilitation centers in Ethiopia
Temesgen Kabeta Chala, Jimma University, Ethiopia
Background: Despite widely available and effective treatment, leprosy remains a major public health issue in Ethiopia. The disease is often misconstrued as a hereditary disease in origin, a curse, or a form of divine punishment for immoral behavior. In this study, we aim to explo [....] » Read More
Title : Assessment of normalization factors in SARS-CoV-2 trends at four treatment plants: Basis for a wastewater surveillance in Mexico City
Martha Mercado, UNAM, Mexico
Background: The potential of wastewater-based epidemiology (WBE) as a surveillance and early warning tool for the COVID-19 outbreak and antimicrobial resistance has been demonstrated in numerous publications. Since WBE is an emerging research area, connecting wastewater data t [....] » Read More
Title : Linezolid-induced bicytopenia in a patient with end-stage renal disease: A case report
Shahreen Islam Raisa, The Grand Rehabilitation and Nursing, United States
Aim: Linezolid (LZD) is an oxazolidinone antibiotic with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). While thrombocytopenia is a recognized side effect, concurrent anemia leading to bicytopenia is less frequently documented. The aim of this study i [....] » Read More
Title : Investigating fusion loop modifications as a strategy to limit flavivirus neuroinvasion
Neelesh Sathish, South Windsor High School, United States
Flaviviruses such as Zika and Powassan virus can cause serious neurological disease because they are able to cross protective barriers in the body including the blood brain barrier and the placenta. This allows the virus to infect the brain and developing fetus, leading to condit [....] » Read More
Title : Detection limits of PaRTI-SeqTM in host-depleted blood: A biological perspective using mycobacterium smegmatis
Shivadarshini Ramachandran, Northumbria University, United Kingdom
Bloodstream infections, particularly in sepsis, need fast and accurate pathogen identification. Although culture-based diagnostics remain the gold standard, they are limited by delayed results, contamination risk and low sensitivity in low-biomass or polymicrobial infections. [....] » Read More
Title : Rabies surveillance and dog population management: Insights from a survey of roaming dogs in Qatar 2024
Mahmoud Mohamed, Ministry of Municipality, Qatar
In 2024, a total of 1,333 roaming dogs were sampled across Qatar to estimate their population size and test for rabies. Surveyed areas were randomly selected to ensure representation across all municipalities and zones, encompassing 419 of 4,000 total blocks. A portable laborator [....] » Read More
Title : Peptide-protein conjugates as vaccine candidates against hookworm infection
Yu Chen Wu, The University of Queensland, Australia
Background: Human hookworm infection, primarily caused by the hematophagous nematode Necator americanus, remains a leading neglected tropical disease (NTD) characterized by chronic iron-deficiency anaemia and malnutrition. While current anthelmintic drug treatments provide tempor [....] » Read More
Title : Camostat-polysaccharide dual-action nasal spray for mucosal barrier-driven prevention of viral infections
Yujeong Na, Daewoong Pharmaceutical Company, Korea, Republic of
Antiviral activity was demonstrated in human nasal epithelial cells and a mouse influenza model. The formulation inhibited viral entry in vitro and suppressed TMPRSS2 expression in vivo, a key factor for viral penetration. Cytotoxicity tests confirmed no toxicity, following ISO 1 [....] » Read More
Title : Phenotypic and genotypic characterization of parainfluenza virus 5 isolated from diarrheic piglets highlights its zoonotic potential
Yassein M Ibrahim, Chinese Academy of Agricultural Sciences, China
Background: Parainfluenza virus 5 (PIV5), is a negative‐sense, non-segmented, single‐stranded RNA virus a member of the Paramyxoviridae family, causes respiratory and neurological infection in several animal species. Whereas information on PIV5 infection in digestive system i [....] » Read More
Title : Nuclear tug-of-war: Competitive VDR/RXR–NFAT1 regulation of coronin-1 governs mycobacterial survival
Sayantani Datta, Indian Institute of Technology Kharagpur, India
Coronin-1 (Cor1), also known as p57 or TACO (for Tryptophan Aspartate containing Coat protein), a highly conserved WD-repeat protein enriched in immune cells, orchestrates host–pathogen interactions and immune signalling; yet the molecular circuitry controlling its transcri [....] » Read More
Title : Mycobacterium tuberculosis virulence factor ESAT-6 induces biphasic immunometabolic reprogramming to redirect macrophage polarization
Debayan Das, Indian Institute of Technology Kharagpur, India
Tuberculosis remains one of the world’s deadliest and most persistent infectious diseases, caused by Mycobacterium tuberculosis (M.tb). Among its key virulence determinants, ESAT-6 (Early Secreted Antigenic Target-6) is a secreted protein widely recognized for its potent im [....] » Read More
Title : Evaluation of biomedical waste management practices and compliance in a tertiary care oncology centre
Minal Poojary, Advanced Centre For Treatment Research & Education In Cancer, India
Introduction: Biomedical waste generated in hospitals poses significant risks to healthcare workers, patients, caregivers, the community, and the environment. Therefore, adequate knowledge, training, and strict implementation of Biomedical Waste Management (BMWM) practices a [....] » Read More
Title : Assessment of in vitro activity of levonadifloxacin against clinical bacterial isolates from ICU patients in a tertiary care hospital
Sangram Singh Patel, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India
Background: Levonadifloxacin is a novel benzoquinolizine fluoroquinolone with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and other resistant Gram-positive pathogens. While its efficacy against Gram-positive cocci is well documented, limited data ex [....] » Read More
Title : Counting spores: A case of mixed fungal infection – Candidal ecthyma gangrenosum and invasive pulmonary aspergillosis in a patient with acute myeloid leukemia
Emmanuel Joseph M Mamaril, National Kidney and Transplant Institute, Philippines
Introduction: Invasive fungal infections comprise a group of diseases affecting deep-seated tissues, with the most common etiologic agents being Candida and Aspergillus species. These are associated with high morbidity and mortality. Populations commonly affected are those in imm [....] » Read More
Title : Association of high SOFA score (≥10) with elevated proenkephalin levels in septic critically ill patients: A single-center cohort study from Indonesia
Fauzio Nurul Khaira, Andalas University, Indonesia
Background: Sepsis remains a major cause of morbidity and mortality in critically ill patients worldwide due to dysregulated host responses leading to multiorgan dysfunction. Early identification of patients with severe organ failure is essential to improve prognosis and optimize [....] » Read More
Title : Comparative prognostic performance of lactate–proenkephalin, SOFA–proenkephalin, and triple combination models for early mortality prediction in septic critically ill patients
Rohayat Bilmahdi, University of Indonesia, Indonesia
Background: Early mortality prediction in sepsis remains challenging because of the complex interaction between tissue hypoperfusion, organ dysfunction, and systemic inflammation. Conventional prognostic tools such as serum lactate and Sequential Organ Failure Assessment (SO [....] » Read More
Title : First report of West Nile virus infections in horses in Tunisia from 2018 to 2023
Imen Larbi, Pasteur Institute of Tunis, Tunisia
West Nile virus (WNV) is an arthropod borne virus, the most widely distributed of the encephalitic Orthoflaviviruses. It can cause severe neurological symptoms in both humans and horses. It poses an emerging threat to both public and animal health. In this study, we retrospective [....] » Read More
Title : Antimicrobial resistance profiles of Escherichia coli O157 and Salmonella enterica isolated from ruminants and risk for public health in Cameroon, March-August 2023
Nguena Guefack Noumedem Ranyl, National Veterinary Laboratory, Cameroon
Introduction/Background: Antimicrobial resistance (AMR) integrated surveillance approach is helpful to understand the drivers and complexity of AMR at the human-animal-plant and environmental interface, and to guide policy and decision making for better mitigation of the risk on [....] » Read More
Title : Seroprevalence and risk factors of Hepatitis B and C viruses among patients at Angré University Hospital Center, Côte d’Ivoire (2024)
Toure Amidou, Angre University Hospital Center, Cote d'Ivoire
Background: Viral hepatitis B (HBV) and C (HCV) remain major global public health challenges, particularly in sub-Saharan Africa. In Côte d’Ivoire, a high-endemicity area, updating epidemiological data is crucial to guide national response strategies in accordance wit [....] » Read More
Title : Antimicrobial resistance pattern of bacterial isolates among patients attending a tertiary healthcare facility in Southeastern Nigeria
Ifeanyi Anyanwu, Imo State University, Nigeria
Background/; Antimicrobial resistance (AMR) has emerged as a major global public health challenge, leading to increased morbidity, mortality, prolonged hospital stay, and rising healthcare costs. The irrational use of antibiotics and poor antimicrobial stewardship practices have [....] » Read More