Title : The correlation between Human Papilloma Virus (HPV) infection and Epidermodysplasia Verruciformis (EV) disorder: A systematic review and meta-analyses

Abstract:

Background and Objective:
Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by abnormal susceptibility to various types of human papillomavirus (HPV), leading to widespread verrucous lesions and an increased risk of skin malignancies. The correlation between HPV infection and EV is crucial for developing effective management and preventive strategies. This meta-analysis aimed to clarify the association between HPV infection and the incidence and severity of EV, provide insight into the specific HPV types involved, and their clinical outcomes.

Methods:
A comprehensive search of relevant literature in multiple databases (Web of Science, PubMed, and Scopus) was conducted for studies published up to March 2025. The inclusion criteria focused on studies reporting on patients with EV and their HPV status. Data on HPV types, prevalence, and clinical outcomes were also extracted. Moreover, a random-effects meta-analysis was performed to determine the pooled prevalence of HPV infection among EV patients.

Results:
A total of 25 studies were included in the final analysis, including 1200 patients diagnosed with EV. This meta-analysis demonstrated a pooled HPV prevalence of 85% among EV patients, with HPV types 5, 8, and 17 being most frequently detected. The odds of developing keratinocyte carcinoma were significantly higher in HPV-positive EV patients compared with HPV-negative individuals (OR = 3.45, 95% confidence interval (CI [1.76-6.76], P < 0.001).

Conclusion:
This meta-analysis revealed a strong correlation between HPV infection and the development of epidermodysplasia vesiculiformis. The findings indicated the importance of HPV vaccination and regular skin surveillance in patients at risk for EV to reduce the risk of skin malignancies.