Title : Advancing Microbial Pathogenesis Research: Investigating Antimicrobial Resistance in Emerging Infectious Diseases
Abstract:
Antimicrobial resistance (AMR) remains a critical global health challenge, contributing to the persistence and spread of infectious diseases. This study examines the genetic and biochemical mechanisms driving AMR in emerging microbial pathogens, with a focus on multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Using advanced microbiological and molecular techniques, we analyze resistance patterns, biofilm formation, and genetic mutations responsible for antibiotic resistance. The findings highlight the role of horizontal gene transfer and efflux pump activation in the survival strategies of these pathogens.
This research underscores the need for novel therapeutic approaches, including bacteriophage therapy and antimicrobial peptides, to combat resistant strains. Additionally, we explore the impact of hospital-acquired infections (HAIs) on disease transmission and patient outcomes. By integrating clinical and laboratory data, we propose a predictive model for assessing infection risk and optimizing antibiotic stewardship programs.
Our study contributes to the global discourse on infectious disease management by providing insights into emerging resistance mechanisms and potential interventions. These findings can guide policymakers and healthcare professionals in developing targeted strategies to curb the spread of AMR and improve patient outcomes.
