Title : Novel functions of the interferon system against virus infection
Abstract:
The interferon (IFN) system is a central component of the innate immune response to viral infection. Viral invasion triggers both antiviral and inflammatory pathways that establish host protection. While early inflammation is beneficial, excessive inflammatory responses—such as cytokine storms—can drive viral pathogenesis. Our research focuses on understanding how components of the IFN system coordinate the balance between antiviral defense and inflammation. Using both cell-based and mouse models, we have identified novel mechanisms by which the host curbs excessive inflammation to prevent cytokine-mediated damage. These findings have important translational implications for combating respiratory viral infections.