Title : Biofilm undesirable complications in polyps control by the novel potent AMPs
Abstract:
Chronic rhinosinusitis (CRS) is a common, though poorly understood, group of diseases affecting a globally large population. Unlike acute rhinosinusitis (ARS), which can be clearly linked to pathogenic bacteria, the causes of CRS are not as straightforward. Recent studies concerning the inflammatory etiology of CRS relates to factors such as environmental allergies, asthma, fungal infection, and aspirin sensitivity. It is therefore important to understand how these systemic factors influence the sinonasal environment and the bacteria that grow there. Literature review suggest that in ARS the most commonly isolated bacteria are Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae. However, these bacteria are not encountered nearly as often in CRS. In CRS the most isolated bacteria are S. aureus, coagulase negative staphylococcus (CNS), and Gram-negative rods (especially Pseudomonas aeruginosa). Anaerobic bacteria, which are rare in ARS, are also isolated with increased frequency in CRS. Approximately half of the bacteria cultured in CRS are found in isolation, the remainder having polymicrobial bacterial growth containing usually two, and sometimes three or more, species. These bacteria have the characteristics of biofilm formation having multiple drug resistant property. This makes the treatment difficult with serious complications.
A novel AMP isolated from garden soil found to have potential antimicrobial properties against gram positive and gram-negative bacteria. The purified AMPs are peptide in their nature and resistant to high pH and temperature. These AMPs show significant antibacterial activity against resistant strains when comparing their efficacy with standard antibiotics.
This novel AMPs is a very promising alternative for the treatment of Biofilm complications in the treatment Polyps.
