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WCID 2025

Biofilm undesirable complications in polyps control by the novel potent AMPs

Anamta Sayeed, Speaker at Infectious Diseases Conferences
Vydehi Institute of Medical Sciences and Research Centre, India
Title : Biofilm undesirable complications in polyps control by the novel potent AMPs

Abstract:

Chronic rhinosinusitis (CRS) is a common, though poorly understood, group of diseases affecting a globally large population. Unlike acute rhinosinusitis (ARS), which can be clearly linked to pathogenic bacteria, the causes of CRS are not as straightforward. Recent studies concerning the inflammatory etiology of CRS relates to factors such as environmental allergies, asthma, fungal infection, and aspirin sensitivity. It is therefore important to understand how these systemic factors influence the sinonasal environment and the bacteria that grow there. Literature review suggest that in ARS the most commonly isolated bacteria are Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae. However, these bacteria are not encountered nearly as often in CRS. In CRS the most isolated bacteria are S. aureus, coagulase negative staphylococcus (CNS), and Gram-negative rods (especially Pseudomonas aeruginosa). Anaerobic bacteria, which are rare in ARS, are also isolated with increased frequency in CRS. Approximately half of the bacteria cultured in CRS are found in isolation, the remainder having polymicrobial bacterial growth containing usually two, and sometimes three or more, species. These bacteria have the characteristics of biofilm formation having multiple drug resistant property. This makes the treatment difficult with serious complications.

A novel AMP isolated from garden soil found to have potential antimicrobial properties against gram positive and gram-negative bacteria. The purified AMPs are peptide in their nature and resistant to high pH and temperature. These AMPs show significant antibacterial activity against resistant strains when comparing their efficacy with standard antibiotics.

This novel AMPs is a very promising alternative for the treatment of Biofilm complications in the treatment Polyps.

Biography:

Dr Anamta Sayeed has done her MS-Master of Surgery: ENT, Head & Neck from Vydehi Institute of Medical Sciences And Research Bangalore,Karnataka,INDIA. She completed her Bachelor of Medicine And Bachelor of Surgery,MBBS – January 2020 JSS Medical College Mysore with overall First Class with Distinction Gold Medalist in Pathology Highest marks in Microbiology. She has  prompt surgical skills in ENT, Head & Neck Surgery Out patient and Inpatient care Basic life support, Advanced Life Support Vital signs monitoring, Physical examination Management of ENT Emergencies and Chronic diseases Can perform minor and major ENT procedures including Septoplasty, Tympanoplasty, Direct Laryngoscopy, Mastoidecotmy, Micolaryngeal Surgeries, Tracheostomy among the others. Currently She is Resident Ent Doctor, Vydehi Institute of Medical Sciences & Research Bengaluru.She also worked as a Junior Consultant Medical Officer at AIIMS New Delhi and CRHSP(Combined Rural Health Services Project) Ballabgarh in ICMR funded project titled - “A Phase III, Randomized, Double-blind, Three arm, Placebo controlled Trial to Evaluate the Safety and Efficacy of two vaccines VPM1002 and Immuvac in preventing Tuberculosis in Healthy Household Contacts of Newly Diagnosed Sputum Positive Pulmonary TB Patients" from New Delhi |September 2021 - November 2021.She Presented and won third position in the national conference AOICON 2024, Bengaluru for the paper presentation with the title- A review of varying presentations of Granulomatous diseases of Nose and Paranasal Sinuses : An analysis of 10 cases.

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