Valley Fever presents unique challenges in diagnosis and management due to its diverse clinical manifestations and the potential for severe complications. The non-specific flu-like symptoms during the early stages make accurate diagnosis challenging, often leading to underreporting of cases. Furthermore, the disease's regional endemicity means that healthcare professionals outside these areas may have limited experience with its diagnosis and treatment. The risk factors for severe Valley Fever include immunosuppression, pregnancy, and certain ethnic backgrounds. Pregnant women, in particular, are at an increased risk of disseminated disease, emphasizing the importance of prompt diagnosis and appropriate management. Antifungal medications, including azoles and polyenes, are the mainstay of treatment, but the duration and choice of therapy depend on the severity of the infection and the patient's overall health. Research continues to explore improved diagnostic tools and antifungal agents for Valley Fever. Serological tests, molecular diagnostics, and advanced imaging techniques are areas of focus to enhance early detection and accurate diagnosis. Additionally, public health initiatives aim to raise awareness, especially in endemic regions, to promote preventive measures such as avoiding dust exposure and using respiratory protection.