In their natural setting, reoviruses commonly infect the gastrointestinal and respiratory tracts of mammals, including humans. The viruses are often associated with mild, self-limiting illnesses. Human infections typically occur in childhood, and symptoms may include respiratory symptoms, diarrhea, and fever. Reoviruses are highly contagious, spreading through respiratory droplets or fecal-oral transmission. While reovirus infections are generally mild, severe cases can occur, particularly in immunocompromised individuals or those with underlying health conditions. In recent years, researchers have also investigated the potential association between reovirus infections and the development of certain autoimmune diseases. Understanding the epidemiology and clinical manifestations of reovirus infections is essential for public health measures, such as hygiene practices, vaccination strategies, and the development of antiviral treatments. Ongoing research explores the molecular biology of reoviruses, their interactions with the host immune system, and the factors influencing their pathogenicity, contributing to our broader understanding of Viral Infections and their implications for human health.