Amebiasis, caused by the protozoan parasite Entamoeba histolytica, is a common intestinal infection affecting millions of people globally. Transmission occurs through the ingestion of contaminated food or water containing cysts of the parasite. While many infections remain asymptomatic, symptomatic cases can present with diarrhea, abdominal pain, and dysentery. Invasive forms of amebiasis can lead to extraintestinal manifestations, such as liver abscesses, which may be life-threatening if not promptly diagnosed and treated. Diagnosis involves the detection of cysts or trophozoites in stool samples and, in some cases, serological tests to distinguish between current and past infections. Treatment for amebiasis typically involves antiprotozoal medications like metronidazole or tinidazole to eliminate the parasite. Preventive measures include practicing good hygiene, ensuring safe water and food sources, and avoiding high-risk behaviors, especially in areas with poor sanitation. Ongoing research in Protozoal Infections like amebiasis aims to understand the pathogenesis of the disease, improve diagnostic methods, and develop effective treatment options. Public health interventions focus on education, sanitation improvements, and access to clean water to reduce the burden of Protozoal Infections, particularly in resource-limited settings.