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Pilus Infections

Pilus Infections

Pili, or fimbriae, are hair-like appendages on the surface of bacteria that play a crucial role in mediating interactions with host cells during infection. Type 1 pili, found in various Gram-negative bacteria, are particularly implicated in Urinary Tract Infections (UTIs). Escherichia coli, a common cause of UTIs, employs type 1 pili to adhere to uroepithelial cells lining the urinary tract. The pili facilitate bacterial colonization and contribute to the pathogenesis of UTIs. In UTIs, bacteria ascend the urethra and adhere to the bladder, causing inflammation and symptoms such as dysuria, frequency, and urgency. Type 1 pili are essential for the initial attachment of E. coli to the urinary tract epithelium. Understanding the role of pili in UTIs has led to the development of therapeutic strategies targeting these adhesion structures to prevent bacterial attachment and subsequent infection.

Committee Members
Speaker at World Congress on Infectious Disease 2025 - Reza Nassiri

Reza Nassiri

Michigan State University, United States
Speaker at World Congress on Infectious Disease 2025 - Francis J Castellino

Francis J Castellino

University of Notre Dame, United States
Speaker at World Congress on Infectious Disease 2025 - Saurabh Chattopadhyay

Saurabh Chattopadhyay

University of Kentucky College of Medicine, United States
WCID 2025 Speakers
Speaker at World Congress on Infectious Disease 2025 - Johnson J H Wang

Johnson J H Wang

Wang Electro-Opto Corporation, United States
Speaker at World Congress on Infectious Disease 2025 - Victor J Alexander

Victor J Alexander

Capital Stem Cell Research Corporation, United States
Speaker at World Congress on Infectious Disease 2025 - Jacob R Miller

Jacob R Miller

Penn State University, United States
Speaker at World Congress on Infectious Disease 2025 - Anmol Grewal

Anmol Grewal

Abrazo Health, United States

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