Liver Fluke Diseases have a global distribution but are particularly prevalent in regions with a tradition of consuming raw or undercooked freshwater fish. Opisthorchis viverrini infections are endemic in Southeast Asia, while Fasciola hepatica is found in various parts of the world, including Europe, Africa, and Asia. Risk factors for Liver Fluke Diseases include dietary practices, environmental conditions favoring the presence of intermediate hosts, and lack of awareness about the potential health risks associated with raw fish consumption. Poverty, inadequate sanitation, and limited access to healthcare contribute to the persistence of liver fluke infections in certain populations. Public health interventions focus on health education to promote the proper cooking of fish, sanitation improvements to reduce contamination of water sources, and control measures targeting the intermediate hosts. Community-based awareness campaigns aim to change dietary habits and promote the recognition of symptoms for early diagnosis and treatment. Research into liver fluke biology, host-parasite interactions, and diagnostic methods is ongoing to develop more effective control strategies. Global collaboration and interdisciplinary approaches involving healthcare professionals, researchers, and policymakers are essential to mitigate the impact of Liver Fluke Diseases on affected populations and reduce the risk of associated complications.