Hantavirus Infections have a global distribution, with different hantavirus species causing outbreaks in specific regions. In Asia, Hantaan virus and Dobrava-Belgrade virus are associated with HFRS, while in the Americas, Sin Nombre virus, Andes virus, and others are linked to HPS. The diversity of hantaviruses and their respective rodent hosts contributes to the complexity of hantavirus epidemiology. Hantavirus outbreaks often occur in rural or semi-rural areas where humans come into close contact with rodent habitats. Factors such as changes in land use, climate, and ecological conditions can influence rodent populations and, consequently, the risk of hantavirus transmission to humans. The public health implications of Hantavirus Infections include the potential for outbreaks with high morbidity and mortality. Surveillance and early detection of hantavirus cases are crucial for implementing timely interventions and preventing the spread of the virus. Diagnostic tools, public health education, and healthcare provider training contribute to improved recognition and management of Hantavirus Infections. Ongoing research aims to better understand hantavirus ecology, transmission dynamics, and the development of preventive measures, including vaccines. The One Health approach, integrating human, animal, and environmental health, is essential for a comprehensive understanding of Hantavirus Infections and the development of effective strategies to mitigate their impact on public health globally.