Preventing gnathostomiasis primarily involves avoiding the consumption of raw or undercooked freshwater fish and other intermediate hosts. Public health campaigns and education initiatives in endemic regions emphasize proper cooking methods and the risks associated with consuming raw or undercooked aquatic animals. Additionally, freezing or properly cooking fish can kill the infective larvae, reducing the risk of transmission to humans. Gnathostomiasis is prevalent in various parts of Asia, particularly in countries like Thailand, Japan, and China. Cases have also been reported in Central and South America. The global distribution is influenced by local culinary practices, environmental factors, and the prevalence of intermediate hosts in aquatic ecosystems. The zoonotic nature of gnathostomiasis underscores the importance of a multidisciplinary approach involving medical professionals, veterinarians, and public health officials. Ongoing research aims to better understand the epidemiology of the disease, improve diagnostic methods, and develop strategies for controlling the transmission of Gnathostoma larvae in endemic regions.