Fasciolopsis buski, primarily known as a human pathogen, can also affect various animal species, posing veterinary challenges in affected regions. Livestock such as pigs, water buffaloes, and cattle can serve as reservoir hosts for Fasciolopsis, contributing to the persistence of the parasite in the environment. Animals become infected by grazing on contaminated vegetation or drinking contaminated water, further complicating the epidemiology of fasciolopsiasis. In veterinary medicine, Fasciolopsis infections in animals can lead to reduced productivity, weight loss, and liver damage. Effective control measures involve strategic deworming with anthelmintic medications and the implementation of proper grazing and water management practices to limit exposure to infective stages of the parasite. Understanding the zoonotic potential of Fasciolopsis is crucial for comprehensive control strategies. Integrative approaches involving both human and veterinary health, along with community education on hygiene and proper waste disposal, contribute to the reduction of Fasciolopsis infections in both human and animal populations. Collaborative efforts between human and veterinary healthcare professionals are essential to addressing the complex ecological and epidemiological aspects of Fasciolopsis infections in endemic areas.