Eukaryotic cells play a crucial role in the development and implementation of antimicrobial strategies. Within these cells, intricate processes and mechanisms are at work to combat microbial threats. One significant aspect is the role of eukaryotic cells in the immune response. Immune cells, such as macrophages and neutrophils, are eukaryotic in nature and act as front-line defenders against invading microorganisms. These cells employ various antimicrobial mechanisms, including phagocytosis, where the pathogens are engulfed and subsequently destroyed within the cellular compartments. Moreover, eukaryotic cells contribute to the synthesis and release of antimicrobial peptides (AMPs). These peptides play a crucial role in the innate immune system, providing a rapid and broad-spectrum defense against various microbes. Eukaryotic cells, especially those in epithelial tissues, produce AMPs in response to microbial invasion, forming a critical component of the cellular defense arsenal.