Controlling directly transmitted infectious diseases presents ongoing challenges for global health systems. The ease of transmission and the potential for rapid outbreaks make these diseases particularly formidable. Respiratory infections like COVID-19 have highlighted the importance of preventive measures such as mask-wearing, social distancing, and vaccination to curb transmission. Sexually transmitted infections continue to be a public health concern, necessitating comprehensive sexual education, widespread testing, and access to treatment. Additionally, the emergence of drug-resistant strains, as seen in tuberculosis and certain STIs, adds complexity to control efforts. The interconnectedness of our global society and increased travel further contribute to the swift spread of these diseases. Ongoing research, surveillance systems, and international collaboration are crucial for staying ahead of emerging threats and developing effective strategies to control the transmission of directly transmitted infectious diseases.