Cat Scratch Disease (CSD) has a worldwide distribution, with an estimated prevalence of approximately 2-4% of the population each year. Children and individuals with compromised immune systems are more susceptible to severe forms of the disease. The bacterium Bartonella henselae primarily infects domestic cats, and the majority of human cases are linked to cat exposure. Public health initiatives focus on raising awareness about CSD risk factors, transmission modes, and preventive measures. Educating pet owners on responsible cat ownership, including routine veterinary care and flea control, helps reduce the risk of Bartonella henselae transmission. Additionally, understanding the importance of prompt wound care after cat scratches or bites contributes to prevention. While Cat Scratch Disease is generally self-limiting, the potential for severe complications underscores the need for vigilance, especially in high-risk populations. Ongoing research into the epidemiology and pathogenesis of CSD enhances our understanding of this infectious disease, facilitating the development of targeted interventions for both human and feline health.