9th Edition of
World Congress on Infectious Diseases
October 23-25, 2025 | Orlando, Florida, USA
HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.
Beta Lactam Antibiotic
Beta Lactam Antibiotic
The intricate mechanisms of action of beta-lactam antibiotics make them a cornerstone in the fight against bacterial infections. The fundamental principle lies in disrupting bacterial cell wall synthesis, an essential process for bacterial survival. Penicillin-binding proteins (PBPs), located on the bacterial cell membrane, are the primary targets of beta-lactam antibiotics. These antibiotics mimic the structure of D-alanyl-D-alanine, a substrate for the transpeptidation reaction during peptidoglycan synthesis. By binding irreversibly to PBPs, beta-lactam antibiotics prevent the cross-linking of peptidoglycan strands, leading to weakened cell walls and eventual cell lysis. Despite their success, bacterial resistance to beta-lactam antibiotics has emerged as a significant concern. One of the main mechanisms involves the production of beta-lactamase enzymes, which cleave the beta-lactam ring, rendering the antibiotic ineffective. To counteract this, scientists have developed beta-lactamase inhibitors, such as clavulanic acid, which are often combined with beta-lactam antibiotics to enhance their efficacy. Additionally, bacteria may alter or reduce the expression of PBPs, limiting the binding sites for beta-lactam antibiotics. Understanding these resistance mechanisms is crucial for designing new generations of beta-lactam antibiotics and developing strategies to combat bacterial infections effectively. Ongoing research in this field aims to stay ahead of evolving resistance patterns and ensure the continued success of beta-lactam antibiotics in the clinical setting.
Committee Members
Reza Nassiri
Michigan State University, United States
Francis J Castellino
University of Notre Dame, United States
Saurabh Chattopadhyay
University of Kentucky College of Medicine, United States WCID 2025 Speakers
Johnson J H Wang
Wang Electro-Opto Corporation, United States
Victor J Alexander
Capital Stem Cell Research Corporation, United States
Jacob R Miller
Penn State University, United States
Anmol Grewal
Abrazo Health, United StatesSubmit your abstract Today
Newsletter
By signing up, you agree to join our mailing list to receive information and updates.
Title : Novel functions of the interferon system against virus infection
Saurabh Chattopadhyay, University of Kentucky College of Medicine, United States
Title : Genomic study of various virulence factors of acinetobacter baumannii isolated from clinical specimens in patients with VAP and bloodstream infection
Anant Marathe, Parul University, India
Title : Elimination of visceral leishmaniasis from India – The story
Shyam Sundar, Banaras Hindu University, India
Title : A modulation of DNA methylation of vitamin D genes: A connecting link between vitamin D levels and grade of SARS-CoV-2 infection
Sunita Girish, Dr. D. Y. Patil School of Allied Health Sciences, India
Title : Congenital HHV-6 infection and the clinical significance of HHV6 positivity on the film array meningitis/encephalitis panel
Erika Nnodi, University of Illinois, United States
Title : The importance of assessing the mental health of nurses and midwives from COVID 19
Anila Cake, Tirana University of Medicine, Albania
Title : Splenectomy in a patient with idiopathic thrombocytopenic purpura and critical thrombocytopenia of 1,000/mm³: A case report
Naser Khan Ghafoor Jamal, Tbilisi State Medical University, Georgia
Title : Conserved antisense RNAs significantly inhibit pan-coronaviruses
Hongwu Xin, Qilu Medical University, China
Title : Key thoughts and strategies based on PBL for rapid managing of suspected gram-positive bacterial infection in ICU
Hua Luo, Peking University, China
Title : Critical bloodstream infection caused by chromobacterium violaceum: A case report in a 15-year-old male with sepsis-induced cardiogenic shock and purpura fulminans
Xueqing Wang, Peking University, China
Title : Effect of wechat consultation group on residents staying at home in Sichuan and Chongqing regions during the coronavirus disease 2019 (COVID-19) outbreak in China: A cross-sectional study
Xiaolei Hu, Shapingba Hospital, China
Title : Sepsis or HLH? Solving the diagnostic puzzle in multiorgan failure
Xiaojun Shen, Peking University, China
Title : Increased incidence of nontyphoidal salmonella infections following COVID-19 outbreak: Is it an impact of the pandemic?
Kundoly Velayudhan Suseela, Amala Institute of Medical Sciences, India
Title : Species identification of lactose non-fermenting isolates from ventilator-associated pneumonia using VITEK 2 and MALDI TOF MS: A comparative study with next-generation sequencing
Asmabanu Shaikh, Parul University, India
Title : Whole genome sequencing for genetic analysis of virulence factors of nosocomial extensively resistant klebsiella pneumoniae isolated from different clinical specimens from ICUs
Bhavita Prajapati, Parul University, India
Title : Management of infected aortobifemoral bypass graft with ureteral fistula in a patient with complex vascular history: A case report
Rakshand Shetty, KMC Hospital, India
Title : Multifocal invasive syphilis in an HIV-positive male mimicking septic emboli and testicular malignancy: A diagnostic and therapeutic challenge
Rakshand Shetty, KMC Hospital, India
Title : Clinical profile and selected viral genome sequence analysis of SARS-CoV-2 infected pediatric patients in a tertiary military hospital in Quezon city from January 2021 – July 2023: A cross sectional study
Deen Mark G Toroy, Armed Forces of the Philippines Medical Center, Philippines
Title : Impact of targeted education on blood culture contamination rates: A public hospital quality control study
Fatima Khan, Aligarh Muslim University, India
Title : Post COVID-19 syndrome is associated with sex and severity of first COVID-19 episode in Honduras
Manuel Antonio Sierra Santos, Central American Technological University, Honduras
Title : A rare case of Cryptococcus gattii meningoencephalitis complicated by immune reconstitution inflammatory syndrome and possible anti-NMDA receptor encephalitis
Achi Kamaraj, Royal Brisbane & Women's Hospital, Australia
Title : Polysaccharide lyase PL3.3 enhancing Clostridioides difficile spore germination and infections recurrence based on complete genome analysis of RT046/ST35 and RT012/ST54
Luo Ying, Zibo Central Hospital, China
Title : A comparative study of tuberculous and pyogenic spondylodiscitis
Farhat Oumayma, Farhat Hached Hospital, Tunisia
Title : Prevalence, risk factors, and antibiotic resistance of Neisseria Gonorrhoeae in patients at STI centers in Addis Ababa, Ethiopia: A cross-sectional case based study
Degefu Beyene, Ethiopian Public Health Institute, Ethiopia
Title : In-silico assessment of the effects of hyptis suaveolens as a natural source of Acetylcholine Esterase (AchE )-targeting insecticide
Caroline Amuche Okoli, University of Jos, Nigeria
Title : Diagnostic value of jones criteria in paediatric rheumatic heart disease patients requiring mitral valve repair
Lydia Munn Ying Chang, Lancashire Teaching Hospitals NHS Trust, United Kingdom
Title : From gut to bladder: Fecal microbiota transplant for C. difficle yields surprising UTI remedy in immunosuppressed patient
David S Buchinsky, Wright State University Boonshoft School of Medicine, United States
Title : Unmasking disseminated cryptococcosis in an immunocompetent host: A diagnostic challenge with life-threatening implications
Randa Elzein, SUNY Upstate University Hospital, United States
Title : ELISA-based monitoring of SARS-CoV-2 IgG antibodies following infection or vaccination
Doina Simona Lazar, Florida International University, United States
Title : Diagnostic value of Jones criteria in paediatric rheumatic heart disease patients requiring mitral valve repair
Lydia Munn Ying Chang, Lancashire Teaching Hospitals NHS Trust, United Kingdom
Title : Demographic and disease characteristics of paediatric rheumatic heart disease (RHD) patients requiring mitral valve surgery in Malaysia
Lydia Munn Ying Chang, Lancashire Teaching Hospitals NHS Trust, United Kingdom
Title : Echocardiographic predictors of children with Rheumatic Heart Disease (RHD) requiring mitral valve repair
Lydia Munn Ying Chang, Lancashire Teaching Hospitals NHS Trust, United Kingdom
Title : First report of ocular pathology in Litopenaeus vannamei attributed to a novel Aeromonas species from the Kovalam Coast, India
Purushothaman Atchuthan, Sathyabama Institute of Science and Technology, India
Title : Human IgG responses to anopheles gambiae immunogenic salivary proteins in urban and rural populations of Burkina Faso: Biomarkers of exposure to malaria vector bites
Hien Yeri Esther, Joseph Ki-Zerbo University, Burkina Faso
Title : A fatal diagnostic pitfall: Disseminated TB presenting as malignancy in a healthcare worker
Adam Chaban, Wayne State University School of Medicine, United States
Title : Stenotrophomonas maltophilia endocarditis: A notorious pathogen with a rare presentation
Chinmayi Kothari, All India Institute of Medical Sciences, India
Title : High-flow nasal therapy in severe respiratory failure due to SARS CoV-2
Walter Juan Molini, Hospital Provincial Neuquen, Argentina
Title : Comprehensive management of jaw bone defects as a post-COVID-19 complication
Sitora, Tashkent Medical Academy, Uzbekistan