Amoebiasis is an infectious disease caused by the protozoan parasite Entamoeba histolytica. This parasitic infection commonly affects the colon (large intestine) and can lead to a range of gastrointestinal symptoms. Transmission occurs through the ingestion of contaminated food or water containing the cysts of E. histolytica. While many individuals infected with the parasite remain asymptomatic, others may experience symptoms such as abdominal pain, diarrhea, bloody stools, and weight loss. In severe cases, amoebiasis can lead to extra-intestinal manifestations, including amebic liver abscess, where the parasite invades the liver and forms an abscess. Diagnosis involves laboratory tests to identify the presence of the parasite or its DNA in stool samples. Antimicrobial medications, such as metronidazole or tinidazole, are commonly used for the treatment of amoebiasis. Preventive measures focus on improving sanitation, promoting hygiene practices, and ensuring the safety of food and water sources. Enhanced awareness and education regarding the transmission and prevention of amoebiasis contribute to its control in endemic regions.