Amebic liver abscess is a severe and potentially life-threatening condition caused by the protozoan parasite Entamoeba histolytica. This parasite primarily infects the colon but can lead to the formation of abscesses in the liver. Individuals acquire the infection through the ingestion of contaminated food or water containing the cysts of E. histolytica. The clinical presentation of amebic liver abscess includes symptoms such as fever, right upper abdominal pain, hepatomegaly, and jaundice. Patients may also experience nausea, vomiting, and weight loss. Diagnosis involves a combination of imaging studies like ultrasound or CT scans, serological tests to detect specific antibodies, and sometimes aspiration of the abscess for microscopic examination. Treatment typically involves antimicrobial therapy with drugs such as metronidazole or tinidazole to eliminate the parasite. In some cases, drainage of the abscess may be necessary for both diagnostic and therapeutic purposes. Prompt and accurate diagnosis is crucial for successful management, as untreated cases can lead to complications and mortality.