Acute upper respiratory infections (URIs) encompass a broad spectrum of illnesses affecting the nose, throat, and sinuses. Viruses, particularly rhinoviruses, coronaviruses, and adenoviruses, are the primary culprits behind these infections, causing symptoms like nasal congestion, sneezing, coughing, and sore throat. Acute URIs are highly contagious, with transmission occurring through respiratory droplets and close personal contact. Influenza, a viral URI caused by influenza viruses, presents with more severe symptoms, including high fever, body aches, and fatigue. Timely diagnosis of influenza is crucial for antiviral treatment, especially in high-risk individuals. Respiratory syncytial virus (RSV) is another viral pathogen that commonly causes acute URIs, particularly in young children and older adults. Management of acute URIs focuses on symptom relief and supportive care. Over-the-counter medications can help alleviate symptoms, but antibiotics are not effective against viral infections. Adequate rest, hydration, and proper hygiene practices contribute to recovery. Prevention strategies involve vaccination against influenza, especially for high-risk populations, and practicing respiratory etiquette to limit the spread of respiratory viruses. Public health efforts, including education on proper hygiene practices and vaccination campaigns, play a vital role in reducing the incidence and impact of acute upper respiratory infections. While most cases are mild and self-limiting, a subset can lead to complications, emphasizing the importance of appropriate preventive measures and prompt medical attention when necessary.