9th Edition of
October 23-25, 2025 | Orlando, Florida, USA
FAST (Facilitated Self-Assembling Technology) is a powerful nanotechnology that enhances the effectiveness of hydrophobic molecules in aqueous formulations. Unlike traditional nanotechnology, FAST requires only one or two water-miscible organic solvents to form stable nanoparticl [....] » Read More
Saudi Arabia effectively managed infectious diseases and pandemics, including MERS-CoV (2014) and COVID-19 (2020), by implementing an integrated, evidence-based approach. Its strategy emphasized strategic planning, international collaboration, and rapid adaptability to evolving h [....] » Read More
SYN023 is a mixture of two anti-rabies humanized monoclonal IgG1κ antibodies which bind to distinct and non-overlapping antigenic sites on the rabies virus glycoprotein. A Phase 2b and a Phase 3 randomized double-blinded trials were conducted to demonstrate the safety [....] » Read More
The acquired immune deficiency syndrome (AIDS) remains to be an incurable fatal infectious disease, while several documented cases demonstrated that the patients with AIDS achieved clinically defined viral clearance following transplantation of hematopoietic stem cells with homoz [....] » Read More
Introduction: Acute Flaccid Paralysis (AFP), a major symptom of poliomyelitis, is caused by the poliovirus. According to the WHO, in 2022, 21,143 cases of AFP were reported worldwide, with 30 cases (%) of wild poliovirus (WPV1) and 828 cases (%) of vaccine-derived poliovirus (cV [....] » Read More
The scientific world believes that microbial correction of microbiota in patients with extrapulmonary forms, including tuberculosis of bones and joints, is important not only for studying the state of health. Now scientists are sure that microbes are important for the treatment o [....] » Read More
Background: Acute febrile illness (AFI) is a major public health challenge in tropical and subtropical regions, particularly during monsoon seasons when vector-borne diseases such as dengue, malaria, and scrub typhus increase. During August-September 2022, an unusual cluster of [....] » Read More
The prevention of mother-to-child transmission (PMTCT) of HIV is one of the most needed public health interventions. Effective implementation of PMTCT services will reduce paediatric HIV infections and improve maternal and child health outcomes. This presentation examines the int [....] » Read More
Leishmaniasis is a tropical parasitic infection transmitted by sand flies. It is sporadically seen in the Aegean, Mediterranean and Central Anatolia regions of Turkey. Here, we wanted to present a non-endemic case of visceral leishmaniasis. A 5-year-old girl was admitted to the h [....] » Read More
Background While Streptococcus gallolyticus subsp. gallolyticus has a well-known association with colorectal cancer, an epidemiological association between S. gallolyticus subsp. pasteurianus and hepatobiliary diseases has been suggested. Herein, we present a unique case of S. g [....] » Read More
Nocardiosis is an uncommon opportunistic infection caused by filamentous Gram-positive bacteria of the genus Nocardia, predominantly affecting immunocompromised hosts. Immunosuppressive therapy, such as Rituximab, significantly increases susceptibility to such infections . Myasth [....] » Read More
Cryptococcosis, a fungal infection, represents a significant and potentially life-threatening condition primarily seen in individuals with compromised immune systems worldwide. The presence of pleural effusion as the sole clinical manifestation is one of the rarest clinical prese [....] » Read More
Background Urinary Tract Infection (UTI) due to Salmonella Typhi is uncommon, though there are scanty reports of bacteriuria caused by nontyphoidal Salmonellae and other gram negative bacilli. However, cases of bacteriuria with UTI due to nontyphoidal Salmonellae were more freq [....] » Read More
Introduction: In March 2020, Ivory Coast recorded its first case of Covid-19. First, located in Abidjan, in the economic capital, the disease gradually spread within the country, affecting almost all health districts, thus testing the entire surveillance system. However, until O [....] » Read More
Introduction Bloodstream infection (BSI) is a common problem for patients in the intensive care unit (ICU). Nearly 60% of primary bloodstream infections are caused by gram-positive cocci. Gram-positive bacteria gain access to the bloodstream through invasive procedures and vario [....] » Read More
Background/Objectives: Antimicrobial resistance (AMR) is a growing global health crisis, particularly in low- and middle-income countries (LMICs) like Pakistan, where excessive and inappropriate antibiotic use contributes to rising resistance. Hospital-based AMR surveillance an [....] » Read More
Acinetobacter baumannii has evolved over years as a predominant nosocomial pathogen in ICUs especially associated with VAPs and subsequent blood stream Infections. In the present work we have tried to observe genetic make-up of A.baumannii isolates for virulence factors and their [....] » Read More
The mechanistic relationship between the methylation process of the vitamin D gene and its impact on the vitamin D levels and COVID-19 infection severity remains a subject of ongoing investigation. However, lack of vaccine and targeted treatment in initial phase of pandemic has s [....] » Read More
The current epidemic of visceral leishmaniasis (VL, kala-azar) in India started in early 1970s and in the late 1990s, it became apparent that there is widespread SbV resistance with its cure rate nose-diving to 35%. There was an urgent need for alternative treatments. In 2002, mi [....] » Read More
Antibiotics are the foundation of modern medicine. Antibiotic resistance (ABR) leads to unintended consequences including suboptimal therapeutic outcomes, increased morbidity and mortality, longer hospital stays, and higher healthcare costs. ABR is a global public health challeng [....] » Read More
Changes in temperature, rainfall and humidity due to climate change affect mosquito-borne disease transmission. However, coastal areas worldwide are also influenced by the expansion of brackish water mosquito habitats as a result of global warming leading to higher sea levels and [....] » Read More
The interferon (IFN) system is a central component of the innate immune response to viral infection. Viral invasion triggers both antiviral and inflammatory pathways that establish host protection. While early inflammation is beneficial, excessive inflammatory responses—suc [....] » Read More
Cytomegalovirus (CMV) infection remains a leading cause of illness and death after liver transplantation (LT). According to current international guidelines, the two most effective strategies to prevent post-transplant CMV infection are antiviral prophylaxis and pre-emptive thera [....] » Read More
The continuing pandemics of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and novel coronavirus disease 2019 (COVID-19) underscore the urgent need for the development of anti-pan-coronavirus drugs that can target emerging coronaviruses and the [....] » Read More
According to the spirit of international sepsis guidelines and clinical practice in China, we explored the rapid diagnosis and treatment ideas and strategies of different pathogenic infections in ICU to shorten the diagnosis time and improve the rescue efficiency. Taking Gram-pos [....] » Read More
Chromobacterium violaceum (C. violaceum) is a gram-negative and facultative anaerobic bacillus that is widespread in the soil and water in tropical and subtropical regions. Knowledge of the pathogenesis of C. violaceum has increased over the decades since the first case of human [....] » Read More
Sepsis and Hemophagocytic Lymphohistiocytosis (HLH) are two critical and life-threatening conditions that often share overlapping clinical features, leading to diagnostic challenges. However, their underlying pathophysiology and treatment approaches differ significantly, making a [....] » Read More
Infection by Nontyphoidal Salmonella (NTS) is considered a zoonotic food poisoning of animal and poultry origin.NTS gastroenteritis is a major cause of diarrheal illness worldwide, which is usually self-limiting. NTS can also cause extraintestinal manifestations and serious compl [....] » Read More
Bacterial identification is essential for effective patient care, particularly in critical care settings with common severe infections. In most Indian laboratory settings, the VITEK 2 system is widely utilized for identifying clinical isolates and antimicrobial susceptibility tes [....] » Read More
Klebsiella pneumoniae is the most common pathogen causing nosocomial infections owing to their potent virulence factors Viz. capsule, Fimbriae, siderophores, Efflux pump, regulatory secretions & secretory system. Since most of the nosocomial K. pneumoniae infections are MDR/X [....] » Read More
Introduction Aortobifemoral (ABF) bypass grafting is a standard surgical approach for severe aortoiliac occlusive disease, though vascular graft infections (VGIs) remain a serious, albeit rare, complication. VGI can lead to life-threatening outcomes such as sepsis and fistula fo [....] » Read More
Background: Syphilis, a sexually transmitted infection caused by Treponema pallidum, remains a diagnostic challenge due to its diverse clinical presentations and ability to mimic various infectious and malignant conditions. In immunocompromised patients, particularly those with [....] » Read More
Introduction: HHV6 is a herpesvirus ubiquitous in children known to cause Roseola Infantum. Congenital HHV6 infection is possible through germline passage of the chromosomally integrated HHV-6 DNA from a parent (ciHHV6). Less commonly, it occurs through transplacental transmissi [....] » Read More
Background/Introduction: COVID-19’s pandemic has had a catastrophic global impact, with nearly one billion reported infections and seven million deaths worldwide. By the middle 2020, several studies described the so-called long COVID syndrome as an emerging and prevalent s [....] » Read More
Spirochete bacteria of the genus Borrelia termed Lyme disease Borreliae (LDB) cause Lyme disease (LD) while other related Borrelia species termed relapsing fever Borreliae (RFB) cause tick-borne relapsing fever (TBRF). LD is widely prevalent in the USA. Because symptoms are mainl [....] » Read More
Transmitted primarily through the bite of a female Anopheles mosquito, malaria is a potentially fatal disease that is endemic throughout most of the tropics. Cases in the United States are rare and are usually the result of international travel to areas such as sub-Saharan Africa [....] » Read More
The mental health welfare of nurses and midwives is an urgent need that requires institutional support for professionals. Recent studies show the connection between SN and Covid 19 damages. This is the project of my PhD topic and the first study, on the impact of the mental healt [....] » Read More
Background: SARS-CoV-2 displays distinct characteristics in terms of virulence and disease severity in pediatric population. Hence, patient’s clinical profile and viral genome may contribute to patient’s symptoms and disease severity. Objectives: To determine the [....] » Read More
Background: Streptococcus acidominimus is mainly recognized as a veterinary pathogen; however, it can lead to severe infections in humans, especially in those with pre-existing health issues. Proper identification and timely treatment are essential for effectively managing thes [....] » Read More
Background: The COVID-19 pandemic has had a significant impact on the world leading to significant morbidity and mortality. The disease was caused by the SARS-CoV-2 virus and can caused severe respiratory illness, as well as a range of other complications depending on presence o [....] » Read More
Recurrent urinary tract infections (UTIs) present significant management challenges, especially when caused by multidrug-resistant (MDR) bacteria, due to the limited availability of effective oral and intravenous (IV) antibiotics. Patients with these infections often undergo mult [....] » Read More
It is broadly acknowledged that IgG antibody levels tend to decline over time, particularly around six months after the second vaccine dose. Emerging data also indicate that individuals previously infected with SARS-CoV-2 often develop a stronger and more sustained immune respons [....] » Read More
Human immunodeficiency virus (HIV) infection can affect the pediatric cardiovascular system through various mechanisms, including chronic inflammation, endothelial dysfunction, and intestinal microbial translocation. These processes lead to complications such as an increased inci [....] » Read More
Actinomycosis is an uncommon infection, usually appearing in the cervicofacial, thoracic, and abdominal regions. Renal involvement of actinomycosis is an extremely rare condition, with a limited number of cases reported in literature to date. Actinomycetes species are generally o [....] » Read More
Introduction: During the COVID-19 pandemic, an increase in healthcare associated infections was observed. A 41% incidence was reported among critically ill patients infected with COVID-19, and 50% of those requiring hospitalization in the intensive care unit were found to be in [....] » Read More
Background: Despite measles elimination in the USA since 2000, recent outbreaks of measles have occurred in several Texas counties. The 2025 measles outbreak in Texas, with over 760 confirmed cases, marks the largest resurgence in over three decades. The last large outbreak in T [....] » Read More
Background: Measles was declared eliminated in the United States in 2000 due to widespread administration of the 2-dose measles-mumps-rubella (MMR) vaccine. However, this vaccine preventable disease has reemerged in recent years due to declining vaccination rates and increased i [....] » Read More
Low-pathogenicity avian influenza A (H9N2) viruses are enzootic in poultry populations in Asia and has undergone extensive genetic reassortment along with various co-circulating subtypes of avian influenza viruses, including highly pathogenic avian influenza H5N1 virus and H7N9 v [....] » Read More
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Title : Binding and activation of fibrinolytic components to group A streptococcus pyogenes enhances microbial pathogenicity
Francis J Castellino, University of Notre Dame, United States
Binding and activation of components of the human fibrinolytic system enhances the pathogenicity of Streptococcus pyogenes (GAS) by allowing a potent serine protease, human plasmin (hPm) to be present on the surface of these cells. The major receptors of hPg and hPm on these cell [....] » Read More
Title : Innovative bactericidal drugs pulse regimens for treatment of leprosy – Advancing towards zero leprosy
Hemanta Kumar Kar, Kalinga Institute of Medical Sciences, India
WHO recommended multi-drug therapy (MDT) in leprosy has proven effective; BUT challenges like treatment adherence, drug resistance, dapsone/ clofazimine bacteriostatic actions/side effects persist. Grosset et al (1) suggested that PMM regimen consisting of Rifapentine, Minocyclin [....] » Read More
Title : Transforming immune therapy: A reverse pathway in B-lymphocytes for super-antibody technology to cure infectious diseases and cancer
Victor J Alexander, Capital Stem Cell Research Corporation, United States
Until today, the contemporary Adaptive Immunology is using Clonal Selection Theory (CST) as a main Theory of Adaptive Immunology for explanation of how Adaptive Immune system is working in mammals. But after 5 years (2010-2015) of my theoretical research results did show that [....] » Read More
Title : Scientific traditional Chinese medicine for low-cost and effective prevention, detection, and treatment of infectious diseases
Johnson J H Wang, Wang Electro-Opto Corporation, United States
COVID-19 pandemic, sweeping the world from November 2019 to April 2025, is estimated to have caused 18 to 34 million deaths. Confirmed deaths were 7.1 million, of which 1.2 million happened in the United States—the richest country with best vaccines, medical equipment and f [....] » Read More
Title : A case of aortic root abscess and repeated prosthetic aortic valve dehiscence in the setting of rare infection with Cellulosimicrobium cellulans and Corynebacterium tuberculostearicum
Nikolas Minanov, Wayne State University School of Medicine, United States
Cellulosimicrobium cellulans and Corynebacterium tuberculostearicum are commensal skin flora that rarely cause human infection. Due to their ubiquitous nature, blood and tissue cultures identifying these organisms are regularly dismissed as contaminants, delaying appropriate anti [....] » Read More
Title : TTV-virome analysis for predicting immune dysfunction and clinical outcomes in COPD patients
Patrizia Russo, San Raffaele University, Italy
Introduction: Torquetenovirus (TTV), the main representative of the Anelloviridae family, is a non-pathogenic virus whose blood viral load reflects immune competence. Elevated TTV levels (≥ 4 log10 copies/mL) have been associated with immunosuppression, clinical frailty, and [....] » Read More
Title : Mycobacterium abscessus complex causing rapidly progressive necrotizing pneumonia
Carson Bridgers, HonorHealth, United States
Introduction: Mycobacterium abscessus complex is a group of fast growing, multidrug resistant mycobacteria that are clinically challenging to treat given rapid progression and antibiotic resistance patterns of this group. Treatment for this group requires a multidrug regimen for [....] » Read More
Title : Water quality and intestinal health: Assessment of access to treated water and the prevalence of endoparasitosis in Manacapuru, interior of the Amazon region
Matheus de Oliveira Nogueira, AFYA Faculty of Medical Sciences, Brazil
Background: Parasitic infections persist as a global public health challenge, with the Brazilian Amazon region showing an alarmingly high prevalence of cases. This situation is particularly critical in the interior areas of Amazonas state, where the precariousness of basic sanit [....] » Read More
Title : Clinical relevance of the 516 G>T polymorphism in CYP2B6 and its effects on efavirenz concentrations in patients with HIV and tuberculosis: A meta-analysis
Yair Lara Blanco, Autonomous University of Baja California, Mexico
Introduction Efavirenz is a long-acting antiretroviral drug that has been available for several decades. Despite being an older medication, it remains widely used in certain regions due to its low susceptibility to resistance. However, its use is associated with frequent adverse [....] » Read More
Title : From myositis to mycosis: Invasive aspergillosis in a patient treated for presumed autoimmune disease
Satya Chitturi, Charles Drew University, United States
We present a diagnostically challenging case of disseminated invasive aspergillosis (DIA) in a 71-year-old male with recent E. coli bacteremia, acute kidney injury requiring hemodialysis (AKI-D), and autoimmune myositis treated with high-dose corticosteroids. The patient was init [....] » Read More
Title : Infectious disease risk among patients prescribed amoxapine or trifluoperazine: A retrospective cohort study using real-world data
Omar Malik, University of Texas Medical Branch, United States
Rising rates of antimicrobial resistance combined with the lack of new antibiotic development has brought new focus to drug repurposing strategies. Early evidence suggests that certain centrally acting psychotropic drugs, including trifluoperazine (TFP) and amoxapine (AXPN), may [....] » Read More
Title : Analysis of measles surveillance data from the regional health center of excellence in man, Ivory Coast, January 2014 to June 2024
Diomande Jean Louty, Ministere De La Sante, Cote d'Ivoire
Introduction: Measles is a contagious viral disease that causes numerous deaths among young children worldwide, particularly in low-income countries, including Côte d’Ivoire, despite the availability of a safe and effective vaccine. The lack of surveillance data anal [....] » Read More
Title : Emphysematous cystitis in an immunocompromised patient with ovarian cancer: A case report
Kole Winebrenner, Nova Southeastern University, United States
Background: Emphysematous cystitis (EC) is a rare, potentially life-threatening urinary tract infection characterized by gas formation within the bladder wall or lumen. While most cases occur in older diabetic patients, EC may also develop in immunocompromised oncology patients, [....] » Read More
Title : The association between antenatal care and HIV testing and treatment during pregnancy: A cross-national analysis of high-burden African settings
Jacob R Miller, Penn State University, United States
Antenatal care (ANC) participation is critical for HIV testing and antiretroviral therapy (ART) initiation to prevent mother-to-child transmission (MTCT), yet significant disparities persist across African nations with high HIV prevalence. With new threats to funding for broad HI [....] » Read More
Title : Mental health and HIV treatment outcomes: The impact of depression on art adherence and viral suppression among women living with HIV in Sub-Saharan African nations
Jacob R Miller, Penn State University, United States
In recent years, remarkable progress has been made toward achieving the UNAIDS 95-95-95 targets for diagnosing, treating, and achieving viral suppression in individuals living with HIV. While African nations with historically high HIV prevalence have shown substantial gains, disp [....] » Read More
Title : Tree shrew: A new primate-like small animal for EBV research
Hirotomo Dochi, Louisiana Cancer Research Center, United States
Epstein-Barr virus (EBV) is implicated in a wide range of human malignancies, including nasopharyngeal carcinoma, Hodgkin lymphoma, and gastric carcinoma. However, progress in elucidating the mechanisms of EBV-associated oncogenesis has been hampered by the absence of an in vivo [....] » Read More
Title : Assessment of the role of free-living forest mammals as a potential source of Yersinia enterocolitica infection
Agata Bancerz Kisiel, University of Warmia and Mazury, Poland
Free-living animals are an important environmental reservoir of the pathogens dangerous for other animal species and humans. One of those is Yersinia (Y.) enterocolitica, the causative agent of yersiniosis – foodborne, enzootic disease, significant for public health. Y. ent [....] » Read More
Title : The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis
Hannah Ghazi Abid, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia
Cryptococcal disease is considered a major cause of morbidity in individuals with HIV in resource-limited settings. The long-term effects of COVID-19 and cryptococcal coinfection among PLWHIV have not been thoroughly investigated. This study examined the incidence of cryptococcos [....] » Read More
Title : A rare polymicrobial bloodstream infection in end-stage renal disease: Enterobacter cloacae, and dual achromobacter species in a hemodialysis patient
Nicole Sonia Northover, American University of the Caribbean, United States
Bloodstream infections are a major source of morbidity and mortality among patients with end-stage renal disease (ESRD) on hemodialysis, particularly when caused by uncommon and multidrug-resistant organisms. Achromobacter xylosoxidans and Achromobacter denitrificans are rare env [....] » Read More
Title : The great masquerader strikes again. Neurosyphilis presenting as general paresis of insane and stroke like syndrome: A case report
Sukesh Gerard, St John’s Medical College Hospital, India
Introduction: Syphilis, often considered “the Great Imitator”, due to its frequent atypical presentation with clinical phenotypes ranging from meningitis, meningovascular syphilis with strokes and in advanced stages as “general paralysis of the insane” to [....] » Read More
Title : Surgical site infection pre and post COVID-19-related hygiene protocols in gynaecological oncology: Is there a difference in prevalence and severity at Charlotte Maxeke Johannesburg Academic Hospital?
Succes Brege Albert Bouangui Bazolana, University of the Witwatersrand, South Africa
Introduction: Surgical site infection is common in gynaecological oncology surgery worldwide. It constitutes a burden to patients and to the healthcare system. The COVID-19 pandemic resulted in a lockdown across the globe to minimise human contact, therefore curbing the spread o [....] » Read More
Title : A rare case of ocular syphilis: Bilateral chorioretinitis and the importance of early diagnosis and treatment
Anmol Grewal, Abrazo Health, United States
Ocular syphilis is a rare but significant manifestation of syphilis that can occur at any stage of the disease, often presenting with diverse clinical features such as uveitis, optic neuropathy, or retinal vasculitis, and in severe cases, may lead to permanent blindness. The inci [....] » Read More
Title : Clostridium difficile bacteremia in a case of acute appendicitis
Pawandeep Kaur, Hamilton Medical Center, United States
Background Clostridium difficile is the principal agent of nosocomial diarrhea. C. difficile is not intrinsically invasive and rarely infects extraintestinal sites. The bacterium, therefore, is not commonly detected in blood cultures. Herein, we report a case of C. difficile bac [....] » Read More
Title : Uncommon complications of invasive streptococcus pneumoniae post dental care
Ali Ejaz, Cleveland Clinic Akron General, United States
The gram-positive cocci S. pneumoniae, is the most common cause of pneumonia, with more than 500,000 cases reported each year in the United States (US). Rarely, S. pneumoniae may present as an invasive infection with a reported incidence of 8.6 cases per 100,000 people in the US. [....] » Read More