West Nile Fever, caused by the West Nile virus (WNV), is a vector-borne illness primarily transmitted to humans through the bite of infected mosquitoes, particularly those of the Culex species. The virus is maintained in a natural transmission cycle between birds and mosquitoes, with humans and other animals serving as incidental hosts. West Nile Fever has a global distribution, with outbreaks occurring in Africa, Europe, the Middle East, and North America. Clinical manifestations of West Nile Fever can range from mild, flu-like symptoms to severe neurological complications, such as encephalitis or meningitis. While the majority of individuals infected with WNV remain asymptomatic, older adults and those with weakened immune systems are at a higher risk of developing severe illness. The virus's ability to cross the blood-brain barrier contributes to its neurological impact, resulting in symptoms like confusion, muscle weakness, and paralysis. Preventive measures for West Nile Fever focus on mosquito control, personal protection against bites, and surveillance to monitor and manage outbreaks. There is no specific antiviral treatment for WNV, and medical care primarily addresses the symptoms and complications. Research continues to explore vaccines and therapeutic interventions to mitigate the impact of this potentially severe arboviral infection.