The treatment of Musculoskeletal Infections is multifaceted and generally involves a combination of antimicrobial therapy, surgical intervention, and supportive care. Antibiotics are administered based on the identified pathogen, and surgical procedures such as drainage, debridement, or joint aspiration may be necessary to remove infected tissues and facilitate healing. In chronic cases or when hardware (such as joint prostheses) is involved, prolonged courses of antibiotics may be required. Complications of Musculoskeletal Infections can be severe and may include chronic pain, joint deformities, and long-term functional impairment. Septic arthritis, if not promptly and adequately treated, can lead to irreversible joint damage. Prevention strategies focus on addressing risk factors and promoting good hygiene practices. Proper wound care, timely treatment of skin infections, and aseptic techniques in surgeries contribute to reducing the risk of Musculoskeletal Infections. In the case of prosthetic Joint Infections, meticulous sterile procedures during joint replacement surgeries and perioperative antibiotic prophylaxis play a crucial role. Research in Musculoskeletal Infections explores new antimicrobial agents, improved diagnostic modalities, and strategies to prevent biofilm formation on medical devices. Interdisciplinary approaches involving orthopedic surgeons, infectious disease specialists, and microbiologists are essential for comprehensive management and prevention strategies. Public health initiatives also emphasize education on recognizing early signs of infection, seeking prompt medical attention, and adhering to prescribed treatment plans to mitigate the impact of Musculoskeletal Infections on patients' outcomes.