African Trypanosomiasis poses a significant threat to public health and socio-economic development in sub-Saharan Africa. The disease primarily affects rural communities with limited access to healthcare, leading to delayed or inadequate treatment. This results in substantial morbidity and mortality, impacting the productivity of affected populations. The economic burden of African Trypanosomiasis is considerable, as it affects agricultural activities, reducing crop and livestock production. Infected livestock suffer from a condition known as nagana, causing loss of meat and dairy production, further exacerbating food insecurity in affected regions. The social impact is profound, as the disease primarily affects the most vulnerable populations. Stigmatization and discrimination often accompany the illness, creating additional challenges for those affected. Efforts to control and eliminate African Trypanosomiasis require a multi-sectoral approach, addressing both healthcare infrastructure and socio-economic factors. International collaboration, investment in research and development, and community engagement are essential for breaking the cycle of transmission and improving the overall well-being of affected populations.