Title : Diagnostic role of cerebrospinal lactate dehydrogenase and serum procalcitonin in meningitis in beni-suiefe governorate
Background: Meningitis means the membranes that cover the brain, spinal cord, and the intervening cerebrospinal fluid becomes inflamed as a result of infection of cerebrospinal fluid by a variety of infectious agents. Acute meningitis is caused by a variety of infectious agents. The most serious form is caused by pyogenic bacteria, such as S.pneumonia, N.meningitides, and H.influenza.
Aim of The work: The primary objective of the present study was to assess the diagnostic role of cerebrospinal LDH serum procalcitonin (PCT-Q) in meningitis in Beni- suief governorate and for differentiating Septic from Aseptic meningitis.
Methods: In this Prospective study evaluation of the diagnostic role of cerebrospinal LDH serum procalcitonin (PCT-Q) in meningitis in Beni- suief governorate and for differentiating Septic from Aseptic meningitis They were divided into four groups: septic meningitis (Group I), Aseptic meningitis (Group II), and meningism (Group III) and 100 control cases who were attending fever hospital for other complain than CNS infection from where blood samples were taken to test S. protein, S .LDH and S.procalcitonin.
Results: it was found that 139 ( 100 %) of 139 of cases were above normal range elevated serum LDH in septic meningitis . while 102( 98 %) of 104 cases were show above normal range elevated serum LDH, while 2 ( 2 %) of 104 cases showed below normal range in Aseptic meningitis group . all cases of meningism show normal range. only 2 control cases were showed
S.LDH above normal and they have complained of chest infection (pneumonia ).also, it was found that S. PCT testing was positive in all patients with septic meningitis while S.PCT testing is positive in 35 patients (34%) with Aseptic meningitis and negative in 69 patients (66%). And S. PCT-Q testing was negative in all patients with meningism. Also, all control cases were assessed as normal S.PCT level