Ghazala Rubi, Lahore General Hospital, Pakistan
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA beta-coronavirus virus that is corona viridae-related. It originated in Wuhan, China in December 2019 and is known to cause COVID-19 illness. SARS-CoV-2posed a major threat to the world in concern of [....] » Read More
Title : The mechanisms of innate immune responses in streptococcus pyogenes pathogenicity
Francis J Castellino, University of Notre Dame, United States
A signature feature of Group A Streptococcus pyogenes (GAS) infections in humans is dysregulated hemostasis. Hemostasis is a component of the innate immune system, which also includes inflammation and complement activation, all of which attempt to eliminate the invadin [....] » Read More
Title : Reducing the dose of mycophenolate in solid organ transplant recipients diagnosed with SARS-CoV-2 infection increases the risk of severe COVID-19
Albert J Eid, University of Kansas Medical Center, United States
Due to conflicting data, it remains unclear whether immunosuppressive medications increase the risk of progression to severe COVID-19 disease in Solid Organ Transplant (SOT) recipients. Most of the available outcome data does not suggest a higher mortality rate in the SOT populat [....] » Read More
Title : Next-generation proteomics for increased access to infectious disease testing for both human and animal health
Jamie Platt, Pictor Inc., United States
Global access to accurate diagnostics for infectious diseases remains a critical challenge, particularly in low-resource settings. Access to accurate, sensitive infectious disease testing, is especially important in managing population health, epidemics and pandemics that have ma [....] » Read More
Title : On a road to enhance VSV as an oncolytic agent: Deciphering the underlying mechanisms of resistance by some cancer cells
Alaa Abdelmageed Ahmed, University of Rochester School of Medicine and Dentistry, United States
Vesicular Stomatitis Virus (VSV) has been suggested for use as an oncolytic agent, due to its wide host range and its ability to suppress host antiviral responses. Conceptually, a good oncolytic agent is able to selectively kill cancer cells while sparing normal healthy ones. It [....] » Read More
Title : Blind spot: A case of ocular syphilis in a patient with HIV
Kadesh Abigail Daniels, Medical College of Georgia, United States
Ocular syphilis is a rare and potentially blinding complication of localized Treponema pallidum infection. Unlike the typical progression of syphilis through the primary, secondary, latent and tertiary stages with distinct, accompanying symptoms, ocular syphilis can occur at unpr [....] » Read More
Title : Coffee industry by-products extracts: Evaluation of the repellent effect against the R (B.) microplus tick
Rosemeire Cristina Linhari Rodrigues Pietro, School of Pharmaceutical Sciences, Brazil
Livestock plays a crucial role in the Brazilian economy, however, the ubiquitous presence of the Rhipicephalus (Boophilus) microplus tick represents a significant challenge, resulting in considerable economic losses. Additionally, ticks stand out as vectors of different microorga [....] » Read More
Title : Wohlfahrtiimonas chitiniclastica bacteremia: A rare case of a male with maggot-infested lower extremity wounds
Sina Hedayatpour, Methodist Dallas Medical Center, United States
Wohlfahrtiimonas chitiniclastica (W. chitiniclastica) is an emerging gram-negative bacillus rarely found in patients presenting with fly myiasis or parasitic larvae infection. Here, we present the case of a 58-year-old male who presented with W. chitiniclastica bac [....] » Read More
Title : Rare case of clostridium cadaveris in an immunocompromised patient with metastatic rectal adenocarcinoma
Prachi Bhanvadia, Ascension St Agnes, United States
Case of a 50 y/o patient with metastatic rectal adenocarcinoma on 5th line chemotherapy who presented with fever and anemia. Was found to have blood cultures positive for Clostridium cadaveris that remained positive for 10 days despite broad spectrum antibiotics. The case discuss [....] » Read More
Title : Unilateral endophthalmitis caused by streptococcus pneuemonia
Priscilla, Atlanticare Regional Medical Centre, United States
Introduction Endophthalmitis is a rare infection of the interior eye by bacteria or fungi. These infections are usually exogenous and are caused as a complication of ophthalmic procedures or penetrating ocular trauma(1) Endogenous endophthalmitis is a rare condition that [....] » Read More
Title : Hyperlactatemia in septic shock, unmasking the false notion; An intriguing case report
Mazen A Hasan, Garden City Hospital, United States
Sepsis is defined as a life-threatening dysregulated body response and systemic inflammation to an infection. Septic shock is a subset of sepsis which has cellular, metabolic, and circulatory abnormalities leading to the shift of aerobic respiration to an anaerobic pathway with r [....] » Read More
Title : Psoas abscess due to group B streptococcus presenting as diabetic ketoacidosis
Mazen A Hasan, Garden City Hospital, United States
Introduction: Psoas abscess is an uncommon infection that typically presents with fever and back pain. The most frequently identified pathogen is Staphylococcus aureus. We present a diabetic patient presenting with Diabetic Ketoacidosis (DKA) due to a Streptococcus agalactiae pso [....] » Read More
Title : Structural deformations in the superior tubular of the hypothalamus and their impact of autoimmune antibody production: A study of long COVID patients
Christof Peter Ziaja, UKE Neuroradiology and Institut of Stress and Fatigue Prof Stark, Germany
Post/Long COVID is a complex multisystemic post-viral syndrome characterized by heterogeneous symptoms, potentially associated with viral or immune-mediated disruption. The superior tubular of the Hypothalamus, responsible for the Immune response and control, plays a pivotal role [....] » Read More
Title : To study the bacteriological episodes of urinary tract infection in different age group with relation to gender
Shikha, GNA University, India
A urinary tract infection is a condition in which one or more parts of the urinary system (kidneys, ureters, bladder, and urethra) become infected. Urinary tract infection may be defined as the presence of bacteria undergoing multiplication in urine within the urinary drainage sy [....] » Read More
Title : BacLI: A potential antibacterial agent against hospital-acquired lung infection
Sabiha Imran, Manav Rachna International Institute of Research & Studies, India
Hospital-acquired infections are infections that are not present at the time of admission to a hospital and thus include ventilator-associated pneumonia, hospital-acquired pneumonia, etc. Hospital-acquired pneumonia (HAP), also known as nosocomial pneumonia, is a lower respi [....] » Read More
Title : Anti-streptococcus mutans, anti-adherence and anti-acidogenic activity of uvaria chamae P beauv
Zandiswa M Gulube, University of Witwatersrand, South Africa
Dental caries is the most prevalent oral infection resulting from accumulation and multiplication of bacteria in the oral cavity. It is caused by demineralisation of the tooth due to the acids produced by Streptococcus mutans from fermentable carbohydrates. Pathogenic characteris [....] » Read More
Title : Prevalence and molecular detection of West Nile Virus (WNV) among renal transplant patients in Khartoum state, Sudan
Ala Omer Abdelaziz Mohamed, Al Neelain University, Qatar
Background: West Nile virus (WNV) is an arbovirus from the Flaviviridae family. West Nile now represents one of the most common arboviral diseases worldwide that causes febrile illness. Also, significant number of patients develop severe neurological disease including meningitis, [....] » Read More
Title : Pathoblockers: A novel anti-virulence approach to combat bacterial infections by targeting cholesterol-dependent cytolysins
Umer Bin Abdul Aziz, Freie Universitat Berlin, Germany
Cholesterol-dependent cytolysins (CDC), a protein family of analogous pore-forming toxins that bind to cholesterol-rich membranes and exacerbate infections through diverse mechanisms, including direct toxicity and immune evasion. CDC are major source of virulence in various gram- [....] » Read More
Title : Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
Baihetinisha Tuerdi, The First Affiliated Hospital of Xinjiang Medical University, China
Background: An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various sepsis-related immune cell defects. Alternative splicing (AS), as a sepsis-related immune cell defect, is considered as a potential immunomo [....] » Read More
Title : Epidemiological situation of 2023 dengue fever outbreaks in ECOWAS region: Implications for strengthening preparedness and response
Aishat Bukola Usman, West African Health Organization, Nigeria
Introduction: The Economic Community of West African States (ECOWAS) experienced a significant surge in Dengue Fever (DF) outbreaks in 2023, posing new important challenges to public health systems. This paper reviewed the epidemiological situation during the outbreaks and highli [....] » Read More