Thomas J Webster, Hebei University of Technology and Interstellar Therapeutics, China
Nanomedicine has already provided dozens of FDA approved products improving the lives of billions. Most notably, nanomaterials have been used to develop vaccines for COVID, improved spinal implants, developed anti-infection materials without using antibiotics, and fabricated nume [....] » Read More
Title : HDAC6 inhibition and CitH3-mAb: Advancements in sepsis treatment
Yongqing Li, University of Michigan Medical School, United States
Sepsis, a severe and often fatal condition, has long evaded effective treatment strategies. For over 16 years, our research has been at the forefront of investigating histone deacetylase (HDAC) inhibitors (HDACIs) as a novel approach in sepsis management. We are excited to share [....] » Read More
Title : Reducing the dose of mycophenolate in solid organ transplant recipients diagnosed with SARS-CoV-2 infection increases the risk of severe COVID-19
Albert J Eid, University of Kansas Medical Center, United States
Due to conflicting data, it remains unclear whether immunosuppressive medications increase the risk of progression to severe COVID-19 disease in Solid Organ Transplant (SOT) recipients. Most of the available outcome data does not suggest a higher mortality rate in the SOT populat [....] » Read More
Title : Distinct patterns of SARS-CoV-2 genetic variations
Jun Wan, Indiana University School of Medicine, United States
We explored distinct and comprehensive patterns of SARS-CoV-2 genetic variations, offering insights obtained by sophisticated analyses from diverse perspectives. Our study encompassed an in-depth examination of single nucleotide variants (SNVs), various nucleotide substitutions, [....] » Read More
Title : The mechanisms of innate immune responses in streptococcus pyogenes pathogenicity
Francis J Castellino, University of Notre Dame, United States
A signature feature of Group A Streptococcus pyogenes (GAS) infections in humans is dysregulated hemostasis. Hemostasis is a component of the innate immune system, which also includes inflammation and complement activation, all of which attempt to eliminate the invadin [....] » Read More
Title : Hyperlactatemia in septic shock, unmasking the false notion; An intriguing case report
Mehwish Zeb, Garden city Hospital, United States
Sepsis is defined as a life-threatening dysregulated body response and systemic inflammation to an infection. Septic shock is a subset of sepsis which has cellular, metabolic, and circulatory abnormalities leading to the shift of aerobic respiration to an anaerobic pathway with r [....] » Read More
Title : The recurrence of cervical precancerous lesion among HIV positive and negative Ethiopian women after cryotherapy: A retrospective cohort study
Agajie Bogale, Gujarat Technological University, United States
Background: Early testing and treatment is among the successful strategies for the prevention and control of cervical precancerous and invasive cancer, and a paramount for women with HIV. In Ethiopia, visual inspection with acetic acid for screening and cryotherapy treatment is c [....] » Read More
Title : On a road to enhance VSV as an oncolytic agent: deciphering the underlying mechanisms of resistance by some cancer cells
Alaa Abdelmageed Ahmed, University of Rochester School of Medicine and Dentistry, United States
Vesicular Stomatitis Virus (VSV) has been suggested for use as an oncolytic agent, due to its wide host range and its ability to suppress host antiviral responses. Conceptually, a good oncolytic agent is able to selectively kill cancer cells while sparing normal healthy ones. It [....] » Read More
Title : Knowledge, attitudes, and practices of healthcare workers in the care of people living with HIV in a tertiary government hospital in Metro Manila
Dalvin Roy A Wong, Amang Rodriguez Memorial Medical Center, Philippines
In the past years, the Philippines has gained a reputation as one of the countries with the fastest growing Human Immunodeficiency virus cases across the world. There was a noted decrease in the incidence of HIV and AIDS related deaths in many regions of the world, but the same i [....] » Read More
Title : Is cigarette smoking a potential protective factor for COVID-19 infection and its symptoms in community population? —— A nested case-control study and clinical characteristics analysis
Zhiheng Zhou, Shenzhen Pingshan General Hospital, China
Background: Cigarette smoking is an unhealthy lifestyle behavior, which can cause a high incidence of respiratory, cardiovascular, endocrine diseases and even tumor . In the past three-year COVID-19 pandemic, there were many researches on the relationship between cigarette [....] » Read More
Title : "Combatting corona: Unveiling the microscopic threat and crafting a scientific solution"
Surya Prakash Tadepalli, Jai Surya Multiple Knowledge Development Organization, India
Introduction: The fear surrounding the coronavirus stems from several factors. Despite its microscopic size, it poses a significant threat due to its ability to cause severe illness and its challenging detectability. Lack of knowledge about the virus and its behavior further exac [....] » Read More
Title : BacLI: A potential antibacterial agent against hospital-acquired lung infection
Sabiha Imran, Manav Rachna International Institute of Research & Studies, India
Hospital-acquired infections are infections that are not present at the time of admission to a hospital and thus include ventilator-associated pneumonia, hospital-acquired pneumonia, etc. Hospital-acquired pneumonia (HAP), also known as nosocomial pneumonia, is a lower respi [....] » Read More
Title : Hemoglobin receptor in leishmania: A potential diagnostic marker for leishmaniasis
Abhishek Dey, Kusuma School of Biological Sciences, India
Visceral Leishmaniasis (VL) is caused by the unicellular protozoan parasite Leishmania donovani. The gold standard for diagnosing VL involves microscopic examination of splenic or bone marrow aspirates requiring expert surgeons and hospitalisation. Subsequently, a VL diagnostic k [....] » Read More
Title : Clinical profile and outcomes of central nervous system infections: A single centre hospital-based study
Sagar Paudel, Institute of Medicine, India
Background Central nervous system (CNS) infections, such as meningitis and encephalitis, caused by various pathogens, can lead to serious morbidity and mortality, with diverse symptoms and outcomes. Survivors may face long-term neurological complications, making early treatment c [....] » Read More
Title : Pathoblockers: A novel anti-virulence approach to combat bacterial infections by targeting cholesterol-dependent cytolysins
Umer Bin Abdul Aziz, Freie Universitat Berlin, Germany
Cholesterol-dependent cytolysins (CDC), a protein family of analogous pore-forming toxins that bind to cholesterol-rich membranes and exacerbate infections through diverse mechanisms, including direct toxicity and immune evasion. CDC are major source of virulence in various gram- [....] » Read More
Title : Adaptation of local rabies virus isolates to high growth titer to develop vaccine strain in Ethiopia
Abebe Mengesha Aga, Armauer Hansen Research Institute, Ethiopia
Background: Rabies is 100% fatal zoonotic disease with acute encephalitis in humans and animals. The case is most severe in developing countries where cell culture derived anti-rabies vaccines are unaffordable or the available nervous tissue-derived vaccines are of questionable i [....] » Read More
Title : A multi-epitope vaccine designed through comparative proteomics and computational modeling against the carcinogenic liver fluke opisthorchis viverrini
Alok Kafle, Khon Kaen University, Thailand
Opisthorchis viverrini (Ov), a Southeast Asian liver fluke, thrives within bile ducts, evading host immune responses and promoting cholangiocarcinoma in humans in humans in humans in humans in humans . A tegument of O. viverrini parasite plays a crucial role in host-parasite inte [....] » Read More
Title : Phylogenetic groups, pathotypes and antimicrobial resistance of escherichia coli isolated from western lowland gorilla faeces (gorilla gorilla gorilla) of Moukalaba-Doudou National Park (MDNP)
Leresche Even Doneilly Oyaba Vinda, Interdisciplinary Medical Research Center of Franceville, Gabon
Background: Terrestrial mammals in protected areas have been identified as a potential source of antimicrobial-resistant bacteria. Studies on antimicrobial resistance in gorillas have already been conducted. Thus, this study aimed to describe the phylogroups, pathotypes and preva [....] » Read More
Title : Bacteria or kidney stones: Which came first?
Niranjan Nayak, Manipal College of Medical Sciences, Nepal
Background: Urinary Tract Infection (UTI) due to Salmonella Typhi is uncommon, though there are scanty reports of bacteriuria caused by nontyphoidal Salmonellae and other gram negative bacilli. However, cases of bacteriuria with UTI due to nontyphoidal Salmonellae were more [....] » Read More
Title : The impact of insecticide-treated bed nets on the biting times of plasmodium falciparum-infective mosquitoes and transmission intensities in Kamuli District, Uganda: Implications for Malaria control
Kabbale Fredrick George, Makerere University, Uganda
Malaria remains the leading cause of morbidity and mortality in Uganda, despite the fairly wide coverage of insecticide-treated bed nets (ITNs) or long lasting insecticide-treated nets (LLINs) combined with other interventions. This study aimed to determine the impact of ITNs/LLI [....] » Read More
Title : Mathematical modelling on the effects of cultural practices on HIV treatment in luo-nyanza region
Sally Lago, Strathmore University, Kenya
In the intricate tapestry of the fight against HIV, understanding the subtle yet powerful influence of cultural practices is paramount. Traditional practises such as widow cleansing rituals and wife inheritance have been practises that affect HIV transmission and treatment outcom [....] » Read More
Title : Sensitivity of antimony(III)-sensitive and -resistant MRPA-overexpressing and AQP1-mutated Leishmania strains towards novel organoantimony(V) and organobismuth(V) complexes and their effect on DNA and membrane integrity
Arshad Islam, Governemnt Lady Reading Hospital Medcial Teaching Institution, Pakistan
Aim: To investigate the effect of novel organometallic Sb(V) and Bi(V) complexes on membrane integrity and their interaction with DNA, activity and cytotoxicity against Sb(III)-sensitive and -resistant Leishmania strains. Material & Methods: Ph3M(L)2 type complex [....] » Read More
Title : Extensively drug-resistant gram-negative bacteria: Rapidly spreading blood stream pathogens in Pakistan
Nusrat Mumtaz, University of Karachi, Pakistan
The emergence of extensively drug- resistant gram negative pathogens (XDR) has worsens the treatment of blood stream infections (BSI) which results in high morbidity and mortality. This study aimed to detect the prevalence and resistance pattern of XDR Gram-negative bacteria in b [....] » Read More
Title : Syphilitic hepatitis: A rare case of hepatic injury from a commonly transmitted venereal disease
Karthic Drishna Perumal, Mount Carmel Health, United States
Syphilis is a sexually transmitted disease caused by the non-hepatotropic spirochete Treponema pallidum. The disease is typically divided into early (primary and secondary infection) and late (tertiary infection that can be symptomatic or asymptomatic) stages. Syphilitic hepatiti [....] » Read More
Title : Right thalamic abscess in a caucasian man with rheumatoid arthritis, an intriguing case report
Mehwish Zeb, Garden city Hospital, United States
Brain abscess is a localized collection of pus within the brain tissue. It is a rare condition and approximately 1500-2000 cases are presented annually in the United States. The patients with immunocompromised state have a higher incidence of acquiring brain abscess. The most fre [....] » Read More
Title : Synthetic interferon exhibits potent antiviral activity across both DNA and RNA viruses with reduced pro-inflammatory gene induction
Qingxiang Liu, IntegerBio Inc, United States
The type I interferon (IFN) system is a potent host innate defense mechanism against viral pathogens. Activation of this pathway occurs upon engagement of IFN with the host IFN alpha receptors 1 and 2 (IFNAR1/2), resulting in activation of > 300 interferon stimulated genes (IS [....] » Read More
Title : Unilateral endophthalmitis caused by streptococcus pneuemonia
Priscilla, Atlanticare Regional Medical Centre, United States
Introduction Endophthalmitis is a rare infection of the interior eye by bacteria or fungi. These infections are usually exogenous and are caused as a complication of ophthalmic procedures or penetrating ocular trauma(1) Endogenous endophthalmitis is a rare condition that [....] » Read More
Title : Shift in the rhizosphere soil fungal community associated with root rot infection of plukenetia volubilis linneo caused by fusarium and rhizopus species
Constantine Uwaremwe, University of Arizona, United States
Background: Plukenetia volubilis Linneo is an oleaginous plant belonging to the family Euphorbiaceae. Due to its seeds containing a high content of edible oil and rich in vitamins, P. volubilis is cultivated as an economical plant worldwide. However, the cultivation and growth of [....] » Read More
Title : Coffee industry by-products extracts: Evaluation of the repellent effect against the R (B.) microplus tick
Rosemeire Cristina Linhari Rodrigues Pietro, School of Pharmaceutical Sciences, Brazil
Livestock plays a crucial role in the Brazilian economy, however, the ubiquitous presence of the Rhipicephalus (Boophilus) microplus tick represents a significant challenge, resulting in considerable economic losses. Additionally, ticks stand out as vectors of different microorga [....] » Read More
Title : Effectiveness of momentary intervention on influenza vaccination in the elderly: From willingness to action
Wan Xue Zhang, Peking University, China
Purpose To evaluate the impact of momentary intervention on the willingness and actual uptake of influenza vaccination among the elderly. Methods The willingness to receive influenza vaccination among the elderly was evaluated by a cross-sectional study. A momentary interventi [....] » Read More
Title : PVX_112690 (PvTRAg36.6) - CD71/TFRC interaction study - new insight of plasmodium vivax invasion into human reticulocyte
Manish Tripathi, All India Institute of medical Sciences, India
Aligned with the global objective to eliminate malaria, continuous efforts are made in the field of malaria biology. However, the parasite is similarly advancing itself to be in competition. Our information about parasites is the tip of the iceberg, making this tug of war into th [....] » Read More
Title : Factors influencing outcomes in patients admitted with melioidosis-a single centre retrospective study
Samyuktha Srinivas, Kasturba Medical College, India
Introduction: Melioidosis is largely under-reported in the Indian subcontinent, this region is believed to account for 44% of cases, with an estimated annual incidence of 52,500 cases per year in India. This retrospective study of 50 patients aimed at determining association b [....] » Read More
Title : Structural deformations in the superior tubular of the hypothalamus and their impact of autoimmune antibody production: A study of long Covid patients
Christof Peter Ziaja, UKE Neuroradiology and Institut of Stress and Fatigue Prof Stark, Germany
Background: Post/Long COVID is a complex multisystemic post-viral syndrome characterized by heterogeneous symptoms, potentially associated with viral or immune-mediated disruption. The superior tubular of the Hypothalamus, responsible for the Immune response and control, plays a [....] » Read More
Title : Prevalence and molecular detection of West Nile Virus (WNV) among renal transplant patients in Khartoum state, Sudan
Ala Omer Abdelaziz Mohamed, Al Neelain University, Qatar
Background: West Nile virus (WNV) is an arbovirus from the Flaviviridae family. West Nile now represents one of the most common arboviral diseases worldwide that causes febrile illness. Also, significant number of patients develop severe neurological disease including meningitis, [....] » Read More
Title : Treatment outcomes and associated factors among patients with Drug-Resistant Tuberculosis (DR-TB) at a tertiary government hospital in Nueva Ecija: A seven-year retrospective study
Kelvin Clein M Curitana, Dr. Paulino J. Garcia Memorial Research and Medical Center, Philippines
Drug resistant tuberculosis (DR-TB) poses significant challenges to the control and successful eradication and management of TB worldwide. MDR-TB treatment outcome is the most important indicator in WHO’s End TB strategy. Tracking of treatment outcomes over time is su [....] » Read More
Title : A survivor of disseminated streptobacillus moniliformis infection complicated with aortic valve infective endocarditis, aortic root abscess and aortic pseudoaneurysm
Ma Donna Balagapo Pelicano, Sengkang General Hospital, Singapore
Background: Streptobacillary endocarditis is rare and often associated with fatal complications. Since the year 2000, only twenty cases of endocarditis have been reported. Fifteen cases affected the mitral valve, while five cases involved the aortic valve. Two of the aortic [....] » Read More
Title : Transaminitis among patients with dengue fever visiting a tertiary care centre
Sangita Thapa, Medical University of America, Nepal
Introduction: Transaminitis is the condition where serum aspartate transaminase and alanine transaminase increase indicating the liver dysfunction. One such disease where liver involvement might be observed is dengue, which is mosquito-borne viral infection. The aim of the study [....] » Read More
Title : Population size-driven diversification as a key factor in ICU occupancy peaks during COVID-19
Francois Daudelin, University of North Carolina at Chapel Hill, United States
During the COVID-19 pandemic, elevated ICU occupancy levels significantly increased mortality rates for COVID-19 patients. Costly non-pharmaceutical interventions, such as lockdowns, and elective surgery suspensions were implemented to reduce the height of occupancy peaks. The he [....] » Read More