7th Edition of
October 24-26, 2024 | Baltimore, MD, USA
Human infectious diseases are among the most important problems in our healthcare system and today antibiotics are used for the treatment of a variety of diseases and infections. There is, however, increasing awareness and concern about antibiotic resistance, which prevents effec [....] » Read More
PubMed, Cochrane, and Embase databases were searched for RCTs. Data were extracted from published reports, and quality assessment was performed according to PRISMA guidelines. We used a fixed-effect model to calculate the risk ratio (RR) and the 95% confidence interval (CI). Endp [....] » Read More
1. Shock. 2. Acute respiratory failure. 3. Coma. 4. Swelling-swelling of the brain. 5. Acute hepatic insufficiency. 6. Acute renal failure. Shock is an acutely developing general reflex pathological reaction of the body in response to the action of extreme stimuli with inhi [....] » Read More
Background Bartter syndrome encompasses salt-losing tubulopathies characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperreninemic hyperaldosteronism with normal blood pressure. Acquired Bartter or Bartter-like syndrome (BLS) is commonly associated with t [....] » Read More
Meningococcal infection is an acute respiratory infectious disease disease caused by meningococcal, characterized by a wide range from asymptomatic bacterial carriage to sepsis. AETIOLOGY The causative agent is Neisseria meningitides. 12 serogroups, the most common are A, B, [....] » Read More
Primary cerebral phaeohyphomycosis is a rare infection caused by brown-black pigmented fungi, namely dematiaceous fungi that can cause infrequent but devastating CNS infection due to their recognised neurotropism. Cladophialophora bantiana is recognised as the most common cause o [....] » Read More
West Nile virus (WNV) infections have increased over recent years to the extent that WNV has become one of the most widespread arboviruses in the world, with potential consequences for both human and animal health. While much is known about WNV and the vectors that transmit it fr [....] » Read More
Introduction A report on a rare case of fungemia due to Aureobasidium pullulans and the role of Infectious Disease in the evaluation and medical management of this skin condition. Case presentation A 42-year-old man with past medical history of Chronic Alcohol Abuse diso [....] » Read More
I. MOTIVATION Arboviral diseases, a significant subclass of Neglected Tropical Diseases, impose a considerable health burden globally, particularly in lower-income nations. Dengue, Chikungunya, and Zika trio account for a high proportion of morbidity and mortality in Latin Am [....] » Read More
Introduction Contaminated oysters are a severe threat to public health in the US, with Norovirus outbreaks being a common concern. To prevent these outbreaks, predicting when they might occur is critical. Fortunately, advanced artificial intelligence models can now forecast co [....] » Read More
DNA double stranded breaks (DSBs) occur in lymphocytes exposed to intense electromagnetic fields (EMFs). We study developing pre-B lymphocytes following V(D)J recombination at their Immunoglobulin light chain loci (IgL). Recombination physiologically induces DNA DSBs, and we test [....] » Read More
Introduction: Sepsis associated encephalopathy (SAE) is diffuse brain dysfunction that occurs secondary to an infection but not directly in the CNS1-2. We present a case of SAE caused by MRSA osteomyelitis and septic shock. Case Summary: 15 year old female who is a volley ba [....] » Read More
Background: Options for recurrent C. difficile remain very limited, especially in Canada where bezlotoxumab, REBYOTA™, and VOWST™ are all not yet available. The need for extensive donor testing in order to maintain a stool bank for FMT has been complicated by an [....] » Read More
Pathogen-associated molecular patterns (PAMPs) and self-DNA in the form of damage-associated molecular patterns (DAMPs) are released from immune cells (Monocytes, Macrophages, and other immune cells) under a stressed condition, that are recognized by pattern recognition receptors [....] » Read More
The important factor in the development of resistance to antibiotics is their overuse, especially for viral respiratory infections. Poland has been for many years a country with a problem of antibiotic overuse on compared to other European countries. The aim of the study was to f [....] » Read More
Access to safe drinking water is crucial for promoting human health and well-being. Contaminated drinking water represents a significant risk for waterborne infections. Water disinfection using Ultraviolet Light-Emitting Diodes (UV LEDs) is a new method to disinfect water effecti [....] » Read More
Background: Hepatitis B infection is the most common and serious liver infection in the world. Health care workers are among the most vulnerable groups to acquire Hepatitis B virus (HBV) infection; with an estimated risk of four times higher than that of the general population. V [....] » Read More
Introduction: Herpes zoster (HZ) is a viral condition resulting from varicella-zoster virus (VZV) reactivation. It typically presents with cutaneous symptoms, such as vesicular rash and dermatomal pain. In rare cases, sacral involvement of VZV can lead to a neurogenic bladder, ca [....] » Read More
Background: Brucellosis is a widespread zoonotic disease, endemic in the Mediterranean. Brucella can spread to humans through the consumption of raw meat, dairy products, direct contact with an infected animal, or by inhaling infected aerosols. After entering host cells, bruce [....] » Read More
Up-to-date, experimental autoimmune encephalomyelitis (EAE) represents the most commonly used model for studying autoimmune-mediated myelin degradation in multiple sclerosis (MS). The immunological and neurobiological mechanisms underlying the pathogenesis, progression, and progn [....] » Read More
Bloodstream infections due to bacteria are a highly consequential nosocomial occurrences and the organisms responsible for them are usually multidrug-resistant. The aims of this study were to describe the incidence of bacteremia caused by Gram-negative ESKAPE bacilli during the C [....] » Read More
Rapid development and deployment of vaccines greatly reduced mortality and morbidity during the COVID-19 pandemic. The most widely used COVID-19 vaccines require intramuscular administration. SARS-CoV-2 initially infects the upper respiratory tract where the infection can be elim [....] » Read More
Visceral leishmaniasis (VL), also known as ‘kala azar,’ is the most severe form of leishmaniasis, caused by Leishmania donovani in the Indian subcontinent and transmitted by the Phlebotomous sand flies. The disease is almost always fatal if left untreated. The clinica [....] » Read More
Introduction: NLRP12 gene plays an essential role in the development and action of regulatory T- cells; therefore, mutations in this gene can show signs and symptoms of autoinflammatory syndromes. Familial Cold Autoinflammatory Syndrome 2 (FCAS2) is one of the NLRP12-associa [....] » Read More
Babesiosis is a worldwide tick-borne disease with an increasing incidence in North America. Several species of apicomplexan Babesia parasites, including B. microti and B. duncani, cause human babesiosis. Babesiosis exhibits many non-specific clinical manifestations. Direct a [....] » Read More
This study is a compilation of some interesting leprotic lesions diagnosed by simple fine needle aspiration cytology (FNAC). A series of patients with palpable leprotic lesions, including polar tuberculoid and lepromatous neuritic leprosies, erythema nodosum leprosum (ENL), lepro [....] » Read More
Objective: Systemic Lupus Erythematosus is an autoimmune systemic connective tissue disease that affects many organs. The disease can be seen at any age period with more frequent females at different clinical stages. Many autoantibodies are shown in blood circulation in patients [....] » Read More
Background: Antiretroviral therapy was reported to show varying degree of responses and toxicities. The inter-individual variation of the therapy outcomes is due to different factors including biological factors. Genetic factors are one of the leading causes of this variation. Th [....] » Read More
Background Cytokine storm in vitamin D deficient covid-19 is characterized by increased production of proinflammatory cytokines, where Vitamin D deficiency increases- the risk of Covid -19 severity. However, the epigenetic contribution of methylation of Vitamin D g [....] » Read More
Impacts of the main operating parameters on permeate flux and pollutants rejection of the RO process, as well as fouling on the membrane surface, were examined for removing the significant ionic concentration and remaining natural organic and dissolved organic matter load o [....] » Read More
Background: Human parvovirus B19 (B19V) is a small DNA virus. Acute B19V infection is a risk for pregnant women. After vertical transmission the infected may develop non-immune hydrops fetalis (NIHF), intrauterine fetal death (IUFD), Intra Uterine Growth restriction (IUGR) and sp [....] » Read More
Purpose of the study: To study the dynamics of mortality from HIV infection in Russia before and during the Covid-19 pandemic. Materials and methods: Rosstat data on the number and causes of death of contingents with HIV infection for 2012-2021. For the analysis, the StatTech pr [....] » Read More
SARS-CoV-2 is the causative agent of the novel corona virus disease of 2019 (COVID-19). It first emerged in the city of Wuhan, China in December 2019 and has resulted in millions of infections and deaths worldwide. To invade a cell, this enveloped virus targets cells that display [....] » Read More
Opisthorchiasis, caused by Opisthorchis viverrini, continues to pose a significant public health challenge, particularly in the Lower Mekong Basin of Southeast Asia, necessitating urgent attention and intervention. Research on O. viverrini has primarily focused on proteomic and t [....] » Read More
The aim of the present study is to determine risk factors association with Methicillin-resistant Staphylococcus aureus (MRSA) as compared with methicillin-sensitive Staphylococcus aureus (MSSA) and to compare the minimum inhibitory concentrations (MICs) of van [....] » Read More
Coronavirus disease 2019 (COVID-19) emerged as a pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high mortality worldwide. COVID-19 infection can be asymptomatic or can cause multi-system disease of varying severity. The long-term effects [....] » Read More
Nontuberculous mycobacteria includes rapid growing (RGM) and slow growing mycobacteria. RGMs like M. abscessus and M. fortuitum- chelonae complex can produce natural chronic infections and the infections of implants. They are usually present in soil and water and get introdu [....] » Read More
The outbreak of the COVID-19 pandemic has underscored the importance of effective pandemic crisis management. This research article explores the need for comprehensive pandemic crisis management strategies and the lessons learned from the COVID-19 crisis. It discusses the key com [....] » Read More
Introduction: The SARS-Cov-2 virus is classically associated with respiratory tract infections. Here we present two rare cases of isolated renal failure resulting from severe rhabdomyolysis due to COVID-19, in the absence of respiratory symptoms. Case 1: A 40-year-old Af [....] » Read More
Coagulase-negative staphylococci (CoNS) remain some of the commonest causes of nosocomial bacteremia, and as genomic identification become more precise, new infectious organisms are reported as the causative agent of bacteremia. Here we report the first published case of Staphylo [....] » Read More
Ingestion of antibiotic-resistant (AR) bacteria may lead to transmission of AR genes in the gut microbiota and cause AR bacterial infection, a significant public health concern. However, it is not clear if and how microbes from the food matrix (food microbes) may influence resist [....] » Read More
Introduction: Tularemia is an uncommon disease. An average of 173 cases per year were reported in the US for the past 20 years. A low minimal-infective-dose, high rate of dissemination and the possible mortality make tularemia a potential weapon for bioterrorism.This report summa [....] » Read More
Introduction Acinetobacter radioresistens (AR), as resistant as the name sounds, is a Gram-negative, aerobic bacillus that survives desiccation, hydrogen peroxide, and UV irradiation and thrives in the hospital environment. It evades detection in the laboratory, adding v [....] » Read More
Hepatitis C Virus (HCV) is a leading cause of liver diseases. Like other RNA viruses, HCV has also been known to alter cellular lipidome for its survival. There are evidences regarding involvement of lipid and lipid droplets (LDs) in HCV replication and assembly in the literature [....] » Read More
Bovine leptospirosis is a zoonosis causing economic losses in livestock. This work reports an outbreak of Leptospira interrogans serogroup Sejroe serovar Hardjo in a cattle farm in province of Enna (Sicily). The farm was officially free from Brucellosis, Tuberculosis and Enzootic [....] » Read More
Toxoplasma gondii, a protozoan pathogen causing zoonosis, represents a serious threat for aquatic mammals including dolphins, as it causes severe brain lesions in dolphins leading them to stranding and death. This study aimed to investigate T. gondii DNA presence in organs collec [....] » Read More
Bats are mammals of the order Chiroptera that exhibit distinctive characteristics such as the ability to fly, a wide distribution, a long lifespan and diverse feeding strategies. They are important members of the ecosystem but also are natural reservoirs and carriers of numerous [....] » Read More
Enteric viruses are responsible for sporadic or epidemic-related infections. They are typically transmitted via the fecal-oral route through person-to-person contact or through the consumption of contaminated food (shellfish, vegetables, etc.) or water. Their main health effect i [....] » Read More
Relevance. Not only children are involved in the epidemic process, but also adults, whose encounter with the measles virus is accompanied by the synthesis of antibodies according to the primary or secondary type of immune response. The diagnosis of measles infection in previously [....] » Read More
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Title : Surveillance of healthcare-associated infections: New challenges for the next decade
Astagneau Pascal, Sorbonne University, France
Healthcare-associated infections (HAI) are one of the most frequent adverse events in hospitalized patients. Their potential outcomes could be fatal or severe and represent a significant disease burden. In addition, a part of HAI is due to multidrug-resistant organisms (MDRO), wh [....] » Read More
Title : Ongoing journey – targeting citrullinated histone H3 (CitH3) for early diagnosis and treatment of sepsis
Yongqing Li, University of Michigan Medical School, United States
Over the past decade, our research team has dedicated our efforts towards studying protein post-translational modifications with the goal of early diagnosis and treatment of sepsis. Our comprehensive and intensive research has culminated in the publication of approximately 40 man [....] » Read More
Title : Ozone and oxidation therapies a salvation for infection treatment
Robert Rowen, Private Medical Practice, United States
Medicine faces crisis with emerging “super bugs,” lethal viruses (Ebola), and stealth pathogens such as tick-borne infections. Thousands are dying worldwide of once easily treatable diseases. Ozone therapy, extensively studied, may be a valuable adjunctive or stand-al [....] » Read More
Title : Answers in hours – a prospective clinical study for rapid detection of pathogens and antibacterial resistance in surgical patients using oxford nanopore sequencing
Emma Whittle, Mayo Clinic, United States
Surgical site infections (SSI) are a major source of morbidity in patients undergoing pancreatic head resection. Infections are often caused by organisms detected in the bile duct, resulting in many institutions using prolonged prophylactic antibiotics that are later optimized ba [....] » Read More
Title : Disseminated histoplasmosis presenting as isolated acute liver injury: A case report
Rebecca Yao, Mayo Clinic, United States
The CNS, skin, and adrenal glands. We present a case of disseminated histoplasmosis in an immunocompromised host presenting with isolated acute liver injury. The various manifestations of disseminated histoplasmosis can involve nearly any organ system, including a 59-year-old [....] » Read More
Title : A Phase II, Randomized, Sham-Controlled Dose-Finding Study of the RD-X19 Treatment Device in Individuals with Mild-to-Moderate COVID-19
Jacob Kocher, EmitBio, United States
The EmitBio RD-X19 is a handheld, self-administered device that delivers doses of 425 nm visible light to the posterior oropharynx and surrounding tissues to serve as a potential new treatment option for outpatients with COVID-19. A Phase II, sham-controlled dose-finding study wa [....] » Read More
Title : In vitro characterization of the SARS-CoV-2 nucleocapsid protein
Babl Sabrina, University of Regensburg, Germany
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus with a genome size of approximately 30 kilobases. The genome encodes non-structural proteins at its 5’ end and structural proteins at its 3’ end. Among the struc [....] » Read More
Title : Innate receptor PGLYRP2 is a functional sensor and hepatic scavenger for hepatitis B virus
Ming Shi, Harbin Institute of Technology, China
The stealth property of Hepatitis B virus (HBV) has been questioned. The hepatic immunocompetence and effective innate immune responses are necessary for spontaneous clearance of HBV infection, however, the underlying mechanisms remain unclear. Here we observed a negative correla [....] » Read More
Title : Effects of the natural compound on SARS-CoV-2 spike protein-mediated metabolic alteration in THP-1 cells explored by the 1H-NMR-based metabolomics approach
Gyaltsen Dakpa, National Chung Hsing University, Taiwan
A change in metabolism is one of the hallmarks of coronavirus disease 2019 (COVID-19) that cause severity and mortality. The mechanism of SARS-CoV-2 spike protein-mediated perturbations of metabolic pathways and modulation of antcin A, a steroid-like compound isolated from Taiwan [....] » Read More
Title : A case of SARS-CoV-2 induced guillain-Barre syndrome in a patient with concurrent bacterial infection while undergoing chemotherapy
William Song, Ochsner Clinic Foundation, United States
Guillain-Barre Syndrome (GBS) represents a spectrum of lmmune-mediated neuropathies that affect 1 to 2 in 100,000 people annually worldwide. Known triggers include infections, vaccinations, trauma, bone marrow transplants, systemic diseases, and medications. Recently, SARS-CoV-2 [....] » Read More
Title : A case of leprosy in North Florida
Austin Auyeung, Graduate Medical Education / HCA Florida North Florida Hospital, United States
Introduction The global prevalence of leprosy, also known as Hansen’s disease is <1/10 000, with the majority of new cases in India, Brazil and Indonesia. It can be broadly categorized as tuberculoid or lepromatous based on histopathological analysis. The USA continue [....] » Read More
Title : Diagnostic performance of real-time PCR kits for the detection SARS-CoV-2 from fecal swab in Covid-19 patient, Rajavithi hospital, Thailand
Suchada Suphanpayak, Rajavithi Hospital, Thailand
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic disease that can manifest with fever, pneumonia and /or gastrointestinal symptoms with vomiting and diarrhea. Currently, the diagnosis is based on RT-PCR tec [....] » Read More
Title : Epidemiology of laboratory confirmed measles virus cases under the age of less than 5 in Ethiopia, 2017-2021
Esete Assefa Yigezu, Ethiopian Public Health Institute, Ethiopia
Background Measles is a highly contagious viral infection causing large outbreaks all over the world. Despite the availability of safe and cost effective vaccine, measles remained endemic with persistent periodic outbreaks in the Horn of Africa. The aim of this study is to chara [....] » Read More
Title : A randomized phase 3 clinical study to evaluate the efficacy and safety of SHR8008 (oteseconazole) vs. fluconazole in subjects with vulvovaginal candidiasis (VVC)
Stephen Brand, Mycovia Pharmaceuticals, United States
Background VIVJOA® (oteseconazole) is approved in the United States to reduce the incidence of recurrent vulvovaginal candidiasis (RVVC). A Phase 3 study was conducted in China by Jiangsu Hengrui Pharmaceuticals Co. Ltd. to evaluate the efficacy and safety of SHR8008 [....] » Read More
Title : Characterization of dengue virus serotype 1 and 2 infection in human dermal fibroblasts
Nicole Messere, Takeda Vaccines, United States
Dengue virus (DENV) is a mosquito-borne flavivirus with four antigenically distinct serotypes called DENV-1, DENV-2, DENV-3, and DENV-4. Many DENV infections are asymptomatic or lead to mild illness, but occasionally DENV infections can lead to severe disease, characterized by sh [....] » Read More
Title : Radiation proctitis with recurrent gastrointestinal bleed complicated by cytomegalovirus: A case report
Austin Auyeung, Graduate Medical Education / HCA Florida North Florida Hospital, United States
Abstract: Cytomegalovirus (CMV) is a well-known DNA virus of the human herpesvirus group that is known to cause a myriad of infections, more commonly in patients who are immunocompromised. Initial infections with this virus are frequently short-lived, presenting in the form a mi [....] » Read More
Title : The Activity of PHMB and other guanidino containing compounds against acanthamoeba
Dharanga Rumeshi Ratnayake, University of Wolverhampton, United Kingdom
In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG), polyaminopropyl biguanide [....] » Read More
Title : Exploring the impact of plectranthus amboinicus L. Extracts on antioxidant system and cell membrane integrity of P. aeruginosa PA01 and S. aureus NCTC8325
Sheeba Samuel Sawant, University of Wolverhampton, United Kingdom
Plectranthus amboinicus (Indian borage) has been extensively studied for its medicinal properties, which can be exploited to develop new antimicrobial therapeutics. The current study investigated the effect of Plectranthus amboinicus leaf extracts on the catalase a [....] » Read More
Title : Innate immune response to hepatitis B virus infection: Recognition and spontaneous viral clearance by hepatic sensor PGLYRP2
Haoran Ren, Harbin Institute of Technology, China
Background & Aims The stealth property of hepatitis B virus (HBV) has been challenged. The age-related hepatic immunocompetence and immune response leads to spontaneous clearance of HBV infection, however, the mechanisms underlying spontaneous clearance remain to be clarif [....] » Read More
Title : A case of meningoencephalitis due to dual infection with streptococcus pneumoniae and herpes simplex Virus 1
William Song, Ochsner Clinic Foundation, United States
Meningoencephalitis is a serious and life-threatening infection with high mortality rates worldwide. Streptococcus pneumoniae is one of the most common infectious agents causing bacterial meningoencephalitis. Herpes Simplex Virus 1 (HSV-1) causes viral meningoencephalit [....] » Read More
Title : Infectious diseases as a medical, social-economic and humanitarian problem
Huseynov Elchin Mammad, Azerbaijan Medical University, Azerbaijan
Due to the rapid and widespread distribution, high mortality in the acute period, and persistent residual effects leading to disability and side effects on pregnancy, and the fetus, infectious diseases are always under the close attention of society and all states. In addition, t [....] » Read More