Ranjan Ramasamy, IDFISH Technology, United States
Babesiosis is a worldwide tick-borne disease with an increasing incidence in North America. Several species of apicomplexan Babesia parasites, including B. microti and B. duncani, cause human babesiosis. Babesiosis exhibits many non-specific clinical manifestations. Direct a [....] » Read More
Title : Surveillance of healthcare-associated infections: New challenges for the next decade
Astagneau Pascal , Sorbonne University, France
Healthcare-associated infections (HAI) are one of the most frequent adverse events in hospitalized patients. Their potential outcomes could be fatal or severe and represent a significant disease burden. In addition, a part of HAI is due to multidrug-resistant organisms (MDRO), wh [....] » Read More
Title : Guidance on MS animal model development: Experimental autoimmune encephalomyelitis models induced by different myelin oligodendrocyte glycoproteins exhibit differentiated pharmacological responses
WenQing Yang, Founder/Chief Scientific Officer, ClinBridge Biotech Corp, China
Up-to-date, experimental autoimmune encephalomyelitis (EAE) represents the most commonly used model for studying autoimmune-mediated myelin degradation in multiple sclerosis (MS). The immunological and neurobiological mechanisms underlying the pathogenesis, progression, and progn [....] » Read More
Title : Host-pathogen interactions in streptococcal pyogenes infections
Francis J Castellino, University of Notre Dame, United States
A distinguishing characteristic of severe Group A Streptococcus pyogenes (GAS) infections is dysregulated hemostasis. A series of studies show that components of the blood coagulation and fibrinolytic pathways regulate the severity of the infection. One grou [....] » Read More
Title : Ozone and oxidation therapies a salvation for infection treatment
Robert Rowen, Private Medical Practice, United States
Medicine faces crisis with emerging “super bugs,” lethal viruses (Ebola), and stealth pathogens such as tick-borne infections. Thousands are dying worldwide of once easily treatable diseases. Ozone therapy, extensively studied, may be a valuable adjunctive or stand-al [....] » Read More
Title : Mometasone furoate nasal spray on recovery of long-term olfactory dysfunction due to COVID-19: A systematic review and meta-analysis of a randomized controlled trials
Nicole Vieira Pires, Columbia University in the City of New York, United States
PubMed, Cochrane, and Embase databases were searched for RCTs. Data were extracted from published reports, and quality assessment was performed according to PRISMA guidelines. We used a fixed-effect model to calculate the risk ratio (RR) and the 95% confidence interval (CI). Endp [....] » Read More
Title : Answers in hours – a prospective clinical study for rapid detection of pathogens and antibacterial resistance in surgical patients using oxford nanopore sequencing
Emma Whittle, Mayo Clinic, United States
Surgical site infections (SSI) are a major source of morbidity in patients undergoing pancreatic head resection. Infections are often caused by organisms detected in the bile duct, resulting in many institutions using prolonged prophylactic antibiotics that are later optimized ba [....] » Read More
Title : A case of UTI flaring into emphysematous pyelonephritis, What went wrong?
Ali Abdulsahib, Capital Health Regional Medical Center, United States
Emphysematous pyelonephritis/pyelitis: is a rare necrotizing infection of the renal parenchyma and surrounding tissues, that results in the presence of gas in the renal parenchyma, collecting system, or perinephric tissue. We are presenting 41-year male with past medical history [....] » Read More
Title : Disseminated histoplasmosis presenting as isolated acute liver injury: A case report
Rebecca Yao, Mayo Clinic, United States
The CNS, skin, and adrenal glands. We present a case of disseminated histoplasmosis in an immunocompromised host presenting with isolated acute liver injury. The various manifestations of disseminated histoplasmosis can involve nearly any organ system, including a 59-year-old [....] » Read More
Title : A Phase II, Randomized, Sham-Controlled Dose-Finding Study of the RD-X19 Treatment Device in Individuals with Mild-to-Moderate COVID-19
Jacob Kocher, EmitBio, United States
The EmitBio RD-X19 is a handheld, self-administered device that delivers doses of 425 nm visible light to the posterior oropharynx and surrounding tissues to serve as a potential new treatment option for outpatients with COVID-19. A Phase II, sham-controlled dose-finding study wa [....] » Read More
Title : Aryl hydrocarbon receptor signaling regulates genes in intestinal epithelial cells to mitigate disease severity during colitis
Archana Saxena, University of South Carolina, United States
Current treatment of ulcerative colitis (UC) leaves a clear unmet need to target the colonic epithelial cells (CECs). In our previous study we found that aryl hydrocarbon receptor (AhR) expression on CECs has a vital role during indole-3-carbinol (I3C)-mediated protection against [....] » Read More
Title : Infectious diseases
Jalia Mpanga, Sinjal, United Kingdom
Infectious diseases are disorders that are caused by organisms, usually microscopic in size, such as bacteria, viruses, fungi, or parasites that are passed, directly or indirectly, from one person to another. Humans can also become infected following exposure to an infected anima [....] » Read More
Title : In vitro characterization of the SARS-CoV-2 nucleocapsid protein
Babl Sabrina, University of Regensburg, Germany
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus with a genome size of approximately 30 kilobases. The genome encodes non-structural proteins at its 5’ end and structural proteins at its 3’ end. Among the struc [....] » Read More
Title : Prevalence of malaria in wild long-tailed macaques of peninsular malaysia
Lau Yee Ling, Universiti Malaya, Malaysia
Malaria is one of the deadliest human parasitic diseases causing an estimated 409000 deaths in 2019 (WHO, 2020). There has been recent interest in zoonotic malaria as an emerging disease as we observe a rise in the number of knowlesi malaria cases together with the recent discove [....] » Read More
Title : New optical and nanotechnologies for the treatment of infectious diseases
Paul Michael Petersen, DTU Electro, Denmark
Human infectious diseases are among the most important problems in our healthcare system and today antibiotics are used for the treatment of a variety of diseases and infections. There is, however, increasing awareness and concern about antibiotic resistance, which prevents effec [....] » Read More
Title : Antibiotic induces barter syndrome- A systematic review
Megha Priyadarshi, All India Institute of Medical Sciences, India
Background Bartter syndrome encompasses salt-losing tubulopathies characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperreninemic hyperaldosteronism with normal blood pressure. Acquired Bartter or Bartter-like syndrome (BLS) is commonly associated with t [....] » Read More
Title : Pyrexia of unknown origin in a healthy adult: Cryptic illness- A case report
Rishikesh Dessai, Sir Ganga Ram Hospital, India
Abstract: We describe a 23-year-old male, with no known co-morbid illnesses, who presented with a history of chronic fever and left hip pain of 6 months duration. His past history was significant for a road traffic accident, 11 months prior to his presentation, where he sustained [....] » Read More
Title : A rare case of cerebral phaeohypomycosis - Tissue biopsy to the rescue
Rahul Kumar, Sir Ganga Ram Hospital, India
Primary cerebral phaeohyphomycosis is a rare infection caused by brown-black pigmented fungi, namely dematiaceous fungi that can cause infrequent but devastating CNS infection due to their recognised neurotropism. Cladophialophora bantiana is recognised as the most common cause o [....] » Read More
Title : Non tuberculous mycobacterium infecting mesh hernioplasty: A case report
Pooja Khosla, Sir Ganga Ram Hospital, India
Abstract: Non-tubercular mycobacteria are considered to be of low virulence and rarely cause human disease unless some aspect of host defence is impaired. Since NTM infections are rarely reported to health agencies due to difficult identification, reliable data on incidence and p [....] » Read More
Title : Virulence factors of staphylococcus aureus associated with bovine mastitis
Rajashree Shivkumar Gandge, Mumbai ( Bombay) Veterinary College, India
Mastitis is one of the major health issues in bovines since years in India, causing great economic losses and threat for zoonotic transmission of infections. While a several types of bacterial pathogens are responsible for this condition, Staphylococcus aureus is reported to be a [....] » Read More
Title : A systematic study on blood system of immune mechanism of hand,foot and mouth disease sepsis
Ling liang Yao, Nanhua University, China
Objective: To investigate the compensation rule of blood system induced by immune mechanism in sepsis of hand, foot and mouth disease. Methods: This paper collected between April 2014 to October 2017 EV71 48 cases of children with hand, foot and mouth disease in hospital [....] » Read More
Title : Innate receptor PGLYRP2 is a functional sensor and hepatic scavenger for hepatitis B virus
Ming Shi, Harbin Institute of Technology, China
The stealth property of Hepatitis B virus (HBV) has been questioned. The hepatic immunocompetence and effective innate immune responses are necessary for spontaneous clearance of HBV infection, however, the underlying mechanisms remain unclear. Here we observed a negative correla [....] » Read More
Title : Ongoing journey – targeting citrullinated histone H3 (CitH3) for early diagnosis and treatment of sepsis
Yongqing Li, University of Michigan Medical School, United States
Over the past decade, our research team has dedicated our efforts towards studying protein post-translational modifications with the goal of early diagnosis and treatment of sepsis. Our comprehensive and intensive research has culminated in the publication of approximately 40 man [....] » Read More
Title : Cytokine storm identification, overall coping strategy and precious treatment model for infectious diseases based on manifestations
Huiyi Feng, Shenzhen Hospital of Southern Medical University, China
In recent years, there have been frequent outbreaks of infectious disease pandemic such as SARS and COVID-19, which pose a serious threat to human life and socio-economic development. Despite the lack of a specific medicine to combat virus infections, the medical community and go [....] » Read More
Title : Cytokine storm identification, overall coping strategy and precious treatment model for infectious diseases based on manifestations
Weixi Shen, Shenzhen Hospital of Southern Medical University, China
In recent years, there have been frequent outbreaks of infectious disease pandemic such as SARS and COVID-19, which pose a serious threat to human life and socio-economic development. Despite the lack of a specific medicine to combat virus infections, the medical community and go [....] » Read More
Title : Genomic analysis of WGS of leishmania major
Fatima Zahrae El Bakri, Ibn tofail university, Morocco
Leishmaniases represent a major public health problem not only because of the number of cases recorded each year, but also because of the wide distribution of the disease. It is a parasitic disease caused by around 20 species of flagellated protozoa transmitted by the bite of cer [....] » Read More
Title : Antibiotic resistance profiles of diarrheal pathogens among children aged under five years in muhoroni sub-county hospital, Kisumu county-Kenya.
Silas Onyango Awuor, Kisii University, Kenya
Diarrhoea diseases are the second leading cause of death among children under five being worsened by emergence of multi-drug resistant which are major problem. Consent was taken from parents with children showing signs. Stool samples were collected in which isolation and Suscepti [....] » Read More
Title : First detection of WNV RNA presence in field-collected mosquitoes in Cyprus
Chryso Theodorou Pallari, University of Nicosia, Cyprus
West Nile virus (WNV) infections have increased over recent years to the extent that WNV has become one of the most widespread arboviruses in the world, with potential consequences for both human and animal health. While much is known about WNV and the vectors that transmit it fr [....] » Read More
Title : andida auris outbreak associated with patients with SARS-CoV-2 in the intensive care unit of a high-complex hospital in cucuta, Colombia
Andres Gonzalez, Health Research Center for the Tropics, Colombia
Abstract: Introduction: During the CoVID-19 pandemic, there was an increase in cases of pathogens of public health surveillance, such as Candida auris, associated with an increase in the need for patient management in intensive care units. The aim of the present study was to d [....] » Read More
Title : Role of Infectious disease Intervention and medical management in a rare case of aureobasidium pullulans
Dana Gangoo, Saint James School of Medicine, Saint Vincent and the Grenadines
Introduction A report on a rare case of fungemia due to Aureobasidium pullulans and the role of Infectious Disease in the evaluation and medical management of this skin condition. Case presentation A 42-year-old man with past medical history of Chronic Alcohol Abuse diso [....] » Read More
Title : Effects of the natural compound on SARS-CoV-2 spike protein-mediated metabolic alteration in THP-1 cells explored by the 1H-NMR-based metabolomics approach
Gyaltsen Dakpa, National Chung Hsing University, Taiwan
A change in metabolism is one of the hallmarks of coronavirus disease 2019 (COVID-19) that cause severity and mortality. The mechanism of SARS-CoV-2 spike protein-mediated perturbations of metabolic pathways and modulation of antcin A, a steroid-like compound isolated from Taiwan [....] » Read More
Title : Effectiveness of COVID-19 vaccine doses in children: Case of lake region economic bloc -kenya
Shem Otoi Odhiambo Sam S, Lake Region Economic Bloc- kenya, Kenya
Introduction: Vaccination of experienced delays due to paucity of information regarding safety, effectiveness, immunogenicity, and reactogenicity. Age wise approval prioritized 12-17 years and later 5-11 years. Those below 5 years possess naïve immunity and not conside [....] » Read More
Title : Epidemiological profile of attacks by animals suspected of rabies, January 2017– December 2021, Haiti
Rose Anaelle Pierre Jean Freycinet, Field Epidemiology Training Program Resident (FETP), Haiti
Background: Human rabies is a serious public health problem. The objective of this work is to describe the epidemiological characteristics of cases of aggression by animals suspected of rabies in Haiti for the period from January 2017 to December 2021. Methods: A retrospective d [....] » Read More
Title : Antibiotic resistance of staphylococcus aureus nasal carriage in young children in Bangladesh
Sufia Islam, East West University, Bangladesh
Staphylococcus aureus (S. aureus) is one of the causes of illness and mortality in children. Both continuous and intermittent nasal carriage of S. aureus can act as a reservoir for internal infections as well as external transmission to other people. Its systemic invasion from th [....] » Read More
Title : A case of leprosy in North Florida
Austin Auyeung, Graduate Medical Education / HCA Florida North Florida Hospital, United States
Introduction The global prevalence of leprosy, also known as Hansen’s disease is <1/10 000, with the majority of new cases in India, Brazil and Indonesia. It can be broadly categorized as tuberculoid or lepromatous based on histopathological analysis. The USA continue [....] » Read More
Title : Differential incidences of various species and percentage of anopheles recorded from karachi
Syeda Azra Qamar, Govt College for Women, Pakistan
Malaria is a life threatening disease transmitting from one person to another through the bite of female Anopheles mosquitoes, it is an infectious disease caused by blood parasitic protozoan of the class sporozoa sub order haemosphorina and the genus Plasmodium which infects the [....] » Read More
Title : Diagnostic performance of real-time PCR kits for the detection SARS-CoV-2 from fecal swab in Covid-19 patient, Rajavithi hospital, Thailand
Suchada Suphanpayak, Rajavithi Hospital, Thailand
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic disease that can manifest with fever, pneumonia and /or gastrointestinal symptoms with vomiting and diarrhea. Currently, the diagnosis is based on RT-PCR tec [....] » Read More
Title : A randomized phase 3 clinical study to evaluate the efficacy and safety of SHR8008 (oteseconazole) vs. fluconazole in subjects with vulvovaginal candidiasis (VVC)
Stephen Brand, Mycovia Pharmaceuticals, United States
Background VIVJOA® (oteseconazole) is approved in the United States to reduce the incidence of recurrent vulvovaginal candidiasis (RVVC). A Phase 3 study was conducted in China by Jiangsu Hengrui Pharmaceuticals Co. Ltd. to evaluate the efficacy and safety of SHR8008 [....] » Read More
Title : Assessment of parvovirus B19 activation in human heart tissue samples
Anna Kloc, University of New Haven, United States
Myocarditis is the inflammation of the heart muscle (myocardium). The heart's capacity to pump blood may be affected by such inflammation. Chest pain, breathing difficulty, and irregular heartbeat, known as arrhythmia, can all be symptoms of myocarditis. The cardi [....] » Read More
Title : Outcomes following implementation of an electronic medical record alert system to improve fluoroquinolone stewardship
Juwairiah Mohammad, Infirmary Health, United States
Fluoroquinolone antibiotics are often overprescribed to populations at risk of adverse effects of these drugs (Mathews, 2019). Overtreatment with fluoroquinolone antibiotics such as ciprofloxacin and levofloxacin lead to increased incidence of tendinopathy, muscle weakness, perip [....] » Read More
Title : Characterization of dengue virus serotype 1 and 2 infection in human dermal fibroblasts
Nicole Messere, Takeda Vaccines, United States
Dengue virus (DENV) is a mosquito-borne flavivirus with four antigenically distinct serotypes called DENV-1, DENV-2, DENV-3, and DENV-4. Many DENV infections are asymptomatic or lead to mild illness, but occasionally DENV infections can lead to severe disease, characterized by sh [....] » Read More
Title : Radiation proctitis with recurrent gastrointestinal bleed complicated by cytomegalovirus: A case report
Austin Auyeung, Graduate Medical Education / HCA Florida North Florida Hospital, United States
Abstract: Cytomegalovirus (CMV) is a well-known DNA virus of the human herpesvirus group that is known to cause a myriad of infections, more commonly in patients who are immunocompromised. Initial infections with this virus are frequently short-lived, presenting in the form a mi [....] » Read More
Title : The Activity of PHMB and other guanidino containing compounds against acanthamoeba
Dharanga Rumeshi Ratnayake, University of Wolverhampton, United Kingdom
In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG), polyaminopropyl biguanide [....] » Read More
Title : Exploring the impact of plectranthus amboinicus L. Extracts on antioxidant system and cell membrane integrity of P. aeruginosa PA01 and S. aureus NCTC8325
Sheeba Samuel Sawant, University of Wolverhampton, United Kingdom
Plectranthus amboinicus (Indian borage) has been extensively studied for its medicinal properties, which can be exploited to develop new antimicrobial therapeutics. The current study investigated the effect of Plectranthus amboinicus leaf extracts on the catalase a [....] » Read More
Title : Bacillary angiomatosis-associated immune reconstitution inflammatory syndrome: A case report
Caryl Yu Durante, Eastern Visayas Medical Center, Philippines
Identifying cutaneous lesions among persons living with human immunodeficiency virus (HIV) can present as a diagnostic challenge. Bacillary angiomatosis (BA) is a rare disease characterized by neovascular proliferation of the skin, presenting as tumor-like masses. Since the adven [....] » Read More
Title : Amphotericin B-induced ototoxicitiy in a successfully treated patient for cryptococcal meningitis relapse: A case report
Pauline Cleo Olpoc, Eastern Visayas Medical Center, Philippines
Background: Cryptococcal meningitis is one of the opportunistic infections in patients with HIV that usually presents with neurological symptoms such as headache, change in sensorium, lethargy, fever, nuchal rigidity, nausea and vomiting. Rarely, it may present with blurring [....] » Read More
Title : A case of SARS-CoV-2 induced guillain-Barre syndrome in a patient with concurrent bacterial infection while undergoing chemotherapy
William Song, Ochsner Clinic Foundation, United States
Guillain-Barre Syndrome (GBS) represents a spectrum of lmmune-mediated neuropathies that affect 1 to 2 in 100,000 people annually worldwide. Known triggers include infections, vaccinations, trauma, bone marrow transplants, systemic diseases, and medications. Recently, SARS-CoV-2 [....] » Read More
Title : Antibiotic prescription practices among children with influenza or RSV infection
Aneta Nitsch Osuch, Medical University of Warsaw, Poland
The important factor in the development of resistance to antibiotics is their overuse, especially for viral respiratory infections. Poland has been for many years a country with a problem of antibiotic overuse on compared to other European countries. The aim of the study was to f [....] » Read More
Title : A case of meningoencephalitis due to dual infection with streptococcus pneumoniae and herpes simplex Virus 1
William Song, Ochsner Clinic Foundation, United States
Meningoencephalitis is a serious and life-threatening infection with high mortality rates worldwide. Streptococcus pneumoniae is one of the most common infectious agents causing bacterial meningoencephalitis. Herpes Simplex Virus 1 (HSV-1) causes viral meningoencephalit [....] » Read More
Title : Armed forces of the Philippines medical center
Darwin C Balasta, Armed Forces of the Philippines Medical Center, Philippines
Background: the neutrophil-to-lymphocyte ratio is a simple and inexpensive tool and has reported to have great prognostic value. The aim of this study is to investigate association of NLR to disease progression and mortality in patients with COVID-19 infection. Method: A retro [....] » Read More
Title : Preventing infectious diseases using UV LEDs for water disinfection
Thea Hein Petersen, Technical University of Denmark, Denmark
Access to safe drinking water is crucial for promoting human health and well-being. Contaminated drinking water represents a significant risk for waterborne infections. Water disinfection using Ultraviolet Light-Emitting Diodes (UV LEDs) is a new method to disinfect water effecti [....] » Read More
Title : Identifying barriers to implementing ventilator-associated pneumonia prevention strategies
Desiree Davis, Fountain Hills, United States
Background: The Center for Disease Control and Prevention (CDC) has estimated that 1 in 31 hospital patients has at least one healthcare-associated infection (HAIs) on any given day. Ventilator-associated pneumonia (VAP) is the most commonly encountered HAI and is ranked as one o [....] » Read More
Title : A ten year retrospective analysis of the clinical profile and treatment outcomes of infective endocarditis at a tertiary hospital in KwaZulu- Natal, South Africa
Nerissa Sanrisha Naidoo, niversity of KwaZulu Natal, South Africa
Objective: To examine the clinical profile and treatment outcomes of infective endocarditis (IE) at a tertiary hospital in KwaZulu-Natal. Methods: A ten year retrospective analysis was conducted on cases of definite IE (modified Duke criteria). Results: Ninety-seven subject [....] » Read More
Title : Herpes zoster complicated with an asymptomatic irreversible neurogenic bladder and end-stage renal disease case report
Rabab Elsadek, HCA North Florida Hospital, United States
Introduction: Herpes zoster (HZ) is a viral condition resulting from varicella-zoster virus (VZV) reactivation. It typically presents with cutaneous symptoms, such as vesicular rash and dermatomal pain. In rare cases, sacral involvement of VZV can lead to a neurogenic bladder, ca [....] » Read More
Title : Exploring neurocognitive disruptions in herpes simplex virus-induced encephalosynaptic syndrome (HESINES)
Ryan Forster, Albert Einstein College of Medicine, United States
Our recent work has uncovered a novel aspect of Herpes Simplex Virus (HSV) pathology - the Herpes Simplex Virus-Induced Encephalosynaptic Syndrome (HESINES). This syndrome reveals a complex interplay between viral particles and neuronal circuitry, leading to a range of unique man [....] » Read More