Title : Changing population immunity to COVID-19 in the context of infection, vaccination and emerging SARS-CoV-2 variants

Abstract:

The changing state of protective immunity to COVID-19 in the global population during the time since COVID-19’s origin in 2019 is analysed in the context of the (i) circulation of SARS-CoV-2 in the population, (ii) widespread use of different types of COVID-19 vaccines beginning in December 2020 and continuing to the present time, and (iii) ongoing evolution of SARS-CoV-2 to produce mutant viruses with greater infectivity, replication rate, evasion of immunity and transmissibility. The outlook, and possible vaccine strategies, for the future control of COVID-19 are also examined. The continuing generation of new SARS-CoV-2 variants, and the rapid global spread of the more fit variants, also highlights the need to continue the worldwide effort to sequence viral genomes and determine virological characteristics of the variants. Appropriate monitoring of emerging SARS-CoV-2 variants in animals also seems essential.

Ramasamy, R. Perspective Overview of Changing Population Immunity to COVID-19 in the Context of Infection, Vaccination, and Emerging SARS-CoV-2 Variants. Pathogens 2025, 14, 1197.
https://doi.org/10.3390/pathogens14121197

Biography:

Ranjan Ramasamy graduated in 1971 and then a PhD in 1974 from the University of Cambridge, UK. He was the Chairman of the National Science Foundation of Sri Lanka, Professor of Life Sciences at the Institute of Fundamental Studies in Kandy in Sri Lanka, Professor of Biochemistry in the University of Jaffna in Jaffna Sri Lanka, Professor of Immunology in the University Brunei Darussalam Medical School and held institute appointments at the Babraham Institute, Cambridge, UK and Scripps Clinic and Research Foundation, La Jolla, USA. He has more than 280 publications.