Potential speaker for Infectious Diseases conferences 2020
Ivelina Trifonva
National Centre of Infectious and Parasitic Diseases, Bulgaria
Title : Viral pathogens associated with acute lower respiratory tract infections in Bulgaria


Acute lower respiratory tract infections are a major cause of morbidity and hospital admissions. This study aimed to determine the viral etiology of these infections among the patients of different age groups in Bulgaria during the period October 2016-September 2019. Nasopharyngeal specimens were collected from patients with bronchiolitis, pneumonia, and exacerbation of chronical respiratory diseases (asthma, COPD). The viral etiology was determined by individual Real-Time PCR assays against 12 respiratory viruses. Of the 644 patients examined, 476 (73.9%) were positive for at least one virus. Co-infections with two and three viruses were found in 81 (17%) of the infected patients. Among the 532 children younger than 5 years, respiratory-syncytial virus (RSV) was the predominant pathogen (37.4%), followed by rhinoviruses (14.1%), bocaviruses (8.8%), human metapneumovirus (7%), adenoviruses (6.8%), influenza A(H3N2) (4.7%) and influenza A(H1N1)pdm09 (3.8%) viruses. RSV-B were more prevalent than RSV-A throughout the study period. At least one respiratory virus was identified in 82.9% and 67.2% of the children with bronchiolitis and pneumonia, respectively. Among the patients >5 years, influenza A(H1N1)pdm09 virus was the most frequently detected (16.5%), followed by RSV (8.8%) and influenza A(H3N2) (7.8%). Diagnostic testing for respiratory viruses using molecular methods may lead to the reduced use of antibiotics and may assist in measures to control infection.


Ivelina Trifonova is PhD student at the National Centre of Infectious and Parasitic Diseases, National Laboratory “Influenza and ARD”, Sofia, Bulgaria. She started her Ph.D. study on 01.02.2017. She completed her Masters in 2015 from the University of Plovdiv "Paisii Hilendarski She has published more than 6 papers in reputed journals. She participated in more than 5 international congresses. She has participated in two scientific projects founded by the National Science Found: DH 13/15/ 20.12.2017, project title: “Viral pathogens in respiratory medicine – distribution in Bulgaria, genetic and clinical characteristics” and ? 13/3/15.12.2017, project title: “In vitro antitumor and antiviral activity of cranberries (vaccinium vitis-idaea) origin from Bulgaria”