Title : Global exploration of scabies-associated microbiota: a multi-country, observational cross-sectional analysis to understand the pathobiology of impetigo linked to scabies
Globally, scabies causes substantial morbidity and mortality. In the tropics, scabies frequently promotes opportunistic bacterial infections, leading to cellulitis/necrotizing fasciitis, bacteraemia, kidney disease and/or rheumatic heart disease. With no vaccine, diagnostic tools and limited treatment options, scabies is considered neglected by WHO. Pathobiology is poorly understood, due to an absence of molecular information on mite infestation, bacterial co-infection and the interactions thereof. We undertake a unique ‘microbiome’ research program, applying meta-omics to a global set of samples, providing fundamental insights into the interaction of scabies and bacterial pathogens to enable the discovery of new and effective diagnostic and/or therapeutic tools.