7th Edition of
October 24-26, 2024 | Baltimore, MD, USA
Male infertility, an intricate interplay of genetic, anatomical, and environmental factors, underscores the notable influence of urogenital infections. Azoospermia, a multifactorial disorder characterized by absence of sperm in seminal plasma, silently challenges reproductive hea [....] » Read More
Background and Purposes: The impact of COVID 19 on mortality rate remains one of the primary sources of death globally. It has caused the death of many patients aged 45 to 84 years old, and in the main four foundations for every age cohort except for children under five year [....] » Read More
Background: Uganda is signatory to the International Health Regulations (2005) which mandates us to have the capacity to detect, assess, report and respond to potential public health emergencies. Following the World Health Organization (WHO) Joint External Evaluation (JEE) 201 [....] » Read More
Background: the present study was conducted to determine the seroprevalence of IgG antibodies to Toxoplasma gondii, among pregnant women at the Franceville Maternal and Child Health Center (FMCHC), Gabon. Material and Methods: Conducted from August 1 to September 31, 2023, thi [....] » Read More
During the past four years, the people all over the world have been struggling with COVID-19 and other terrible infectious disease. Fortunately, we have accumulated amounts of clinical experience in the diagnosis and treatment of unexplained pneumonia from COVID-19 that was not b [....] » Read More
Leptospirosis is a zoonotic and neglected waterborne disease caused by the pathogenic helical spirochetes. Several significant risk factors, such as climate, occupation, urbanization, and poverty, can contribute to leptospirosis in humans. Symptoms of acute-phase leptospirosis in [....] » Read More
Background: Antimicrobial resistance (AMR) is a serious and rapidly growing global health threat, according to the World Health Organization (WHO). A study found that 90% of hospitalized infants with sepsis in the Middle East carried antibiotic-resistant bacteria. Yet, public awa [....] » Read More
Background: Vitamin D, recognized for its immunomodulatory effects, plays a crucial role in strengthening the body's defense mechanisms. Emerging evidence suggests that comorbidities associated with COVID-19 often exhibit lower levels of Vitamin D, predisposing them to height [....] » Read More
Background: Hepatitis B is a preventable disease of public health significance; untreated infection leads to liver cirrhosis, liver cancer and death. Young adults can be infected via unprotected sexual intercourse. Our study assessed the Hepatitis B-related knowledge and preventi [....] » Read More
Dengue is the most important of the human arboviral infections and most rapidly spreading mosquito-borne viral disease in the world. It occurs in tropical and subtropical regions of the world and an all-year round disease in the Philippines. In 2020, the Philippines reported 83,1 [....] » Read More
Background: Fusarium spp. are fungal species usually found in soil, water, and plants, which can cause infection, especially in immunocompromised patients. Fusarium infections are commonly seen in hematologic neoplasms; only a few are reported in solid organ malignancies. C [....] » Read More
Introduction: Guillain-Barré syndrome (GBS) following COVID-19 vaccination has been reported in the scientific literature. Although causality cannot be ascertained, this case of GBS is reported, to highlight the diagnosis, management and incidence of this important adve [....] » Read More
Coronavirus disease (COVID- 19) is a severe infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to the cells; angiotensin converting enzyme 2 (ACE2) receptor. In the first severe case of COVID- 19 in Shenzhen city, we found that in [....] » Read More
Hepatitis E Virus (HEV) and Hepatitis A Virus (HAV) infections continue to pose substantial global health concerns, especially in areas of insufficient sanitation and hygiene standards. This case report investigates the seroprevalence of Hepatitis A Virus (HAV) and Hepatitis E Vi [....] » Read More
The COVID-19 pathogen is a pathogen with a single strand of genetic material, belonging to the family coronaviridae. It possesses a genome that is approximately 29881 bp long, which results in the development of a respiratory disease with sudden onset. One of how the COVID-19 vir [....] » Read More
Marburg and Ebola viral fevers are highly severe afflictions that have a detrimental impact on both the human species and non-human primates. These ailments manifest themselves in a multitude of symptoms, encompassing hemorrhages, elevated body temperatures, cranial discomfort, m [....] » Read More
27-year-old hispanic male with no known past medical history initially presented to the emergency department for symptoms of possible panic attack after quitting his job and breaking up with his girlfriend. In the emergency department, he received oral Ativan 1 mg with reported i [....] » Read More
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Title : HDAC6 inhibition and CitH3-mAb: Advancements in sepsis treatment
Yongqing Li, University of Michigan Medical School, United States
Sepsis, a severe and often fatal condition, has long evaded effective treatment strategies. For over 16 years, our research has been at the forefront of investigating histone deacetylase (HDAC) inhibitors (HDACIs) as a novel approach in sepsis management. We are excited to share [....] » Read More
Title : Reducing the dose of mycophenolate in solid organ transplant recipients diagnosed with SARS-CoV-2 infection increases the risk of severe COVID-19
Albert J Eid, University of Kansas Medical Center, United States
Due to conflicting data, it remains unclear whether immunosuppressive medications increase the risk of progression to severe COVID-19 disease in Solid Organ Transplant (SOT) recipients. Most of the available outcome data does not suggest a higher mortality rate in the SOT populat [....] » Read More
Title : Distinct patterns of SARS-CoV-2 genetic variations
Jun Wan, Indiana University School of Medicine, United States
We explored distinct and comprehensive patterns of SARS-CoV-2 genetic variations, offering insights obtained by sophisticated analyses from diverse perspectives. Our study encompassed an in-depth examination of single nucleotide variants (SNVs), various nucleotide substitutions, [....] » Read More
Title : The mechanisms of innate immune responses in streptococcus pyogenes pathogenicity
Francis J Castellino, University of Notre Dame, United States
A signature feature of Group A Streptococcus pyogenes (GAS) infections in humans is dysregulated hemostasis. Hemostasis is a component of the innate immune system, which also includes inflammation and complement activation, all of which attempt to eliminate the invadin [....] » Read More
Title : The Covid-19 experience: What was new and, mostly what was not. a review
Tom Koch, University of British Columbia, Canada
In our focus on the immediate, and the new we forget the history in which Covid-19 and other, infectious diseases occur. Seen from this perspective there was little new in our experiences with overcrowded wards and limited supplies. What was new was a result of changes in the cul [....] » Read More
Title : Hyperlactatemia in septic shock, unmasking the false notion; An intriguing case report
Mehwish Zeb, Garden city Hospital, United States
Sepsis is defined as a life-threatening dysregulated body response and systemic inflammation to an infection. Septic shock is a subset of sepsis which has cellular, metabolic, and circulatory abnormalities leading to the shift of aerobic respiration to an anaerobic pathway with r [....] » Read More
Title : A multi-epitope vaccine designed through comparative proteomics and computational modeling against the carcinogenic liver fluke opisthorchis viverrini
Alok Kafle, Khon Kaen University, Thailand
Opisthorchis viverrini (Ov), a Southeast Asian liver fluke, thrives within bile ducts, evading host immune responses and promoting cholangiocarcinoma in humans in humans in humans in humans in humans . A tegument of O. viverrini parasite plays a crucial role in host-parasite inte [....] » Read More
Title : "Combatting corona: Unveiling the microscopic threat and crafting a scientific solution"
Surya Prakash Tadepalli, Jai Surya Multiple Knowledge Development Organization, India
Introduction: The fear surrounding the coronavirus stems from several factors. Despite its microscopic size, it poses a significant threat due to its ability to cause severe illness and its challenging detectability. Lack of knowledge about the virus and its behavior further exac [....] » Read More
Title : Is cigarette smoking a potential protective factor for COVID-19 infection and its symptoms in community population? —— A nested case-control study and clinical characteristics analysis
Zhiheng Zhou, Shenzhen Pingshan General Hospital, China
Background: Cigarette smoking is an unhealthy lifestyle behavior, which can cause a high incidence of respiratory, cardiovascular, endocrine diseases and even tumor . In the past three-year COVID-19 pandemic, there were many researches on the relationship between cigarette [....] » Read More
Title : Sensitivity of antimony(III)-sensitive and -resistant MRPA-overexpressing and AQP1-mutated Leishmania strains towards novel organoantimony(V) and organobismuth(V) complexes and their effect on DNA and membrane integrity
Arshad Islam, Governemnt Lady Reading Hospital Medcial Teaching Institution, Pakistan
Aim: To investigate the effect of novel organometallic Sb(V) and Bi(V) complexes on membrane integrity and their interaction with DNA, activity and cytotoxicity against Sb(III)-sensitive and -resistant Leishmania strains. Material & Methods: Ph3M(L)2 type complex [....] » Read More
Title : Extensively drug-resistant gram-negative bacteria: Rapidly spreading blood stream pathogens in Pakistan
Nusrat Mumtaz, University of Karachi, Pakistan
The emergence of extensively drug- resistant gram negative pathogens (XDR) has worsens the treatment of blood stream infections (BSI) which results in high morbidity and mortality. This study aimed to detect the prevalence and resistance pattern of XDR Gram-negative bacteria in b [....] » Read More
Title : Determination of incidence of intestinal parasites infestation in population of district Swat Pakistan
Nasib Zaman, University of Swat, Pakistan
Intestinal parasitic infections (IPIs) represent a worldwide health concern, and they are the most prevalent infections within a specific local population. A recent study aimed to determine the occurrence of IPIs and identify the contributing factors responsible for the transmiss [....] » Read More
Title : Phylogenetic groups, pathotypes and antimicrobial resistance of escherichia coli isolated from western lowland gorilla faeces (gorilla gorilla gorilla) of Moukalaba-Doudou National Park (MDNP)
Leresche Even Doneilly Oyaba Vinda, Interdisciplinary Medical Research Center of Franceville, Gabon
Background: Terrestrial mammals in protected areas have been identified as a potential source of antimicrobial-resistant bacteria. Studies on antimicrobial resistance in gorillas have already been conducted. Thus, this study aimed to describe the phylogroups, pathotypes and preva [....] » Read More
Title : The impact of insecticide-treated bed nets on the biting times of plasmodium falciparum-infective mosquitoes and transmission intensities in Kamuli District, Uganda: Implications for Malaria control
Kabbale Fredrick George, Makerere University, Uganda
Malaria remains the leading cause of morbidity and mortality in Uganda, despite the fairly wide coverage of insecticide-treated bed nets (ITNs) or long lasting insecticide-treated nets (LLINs) combined with other interventions. This study aimed to determine the impact of ITNs/LLI [....] » Read More
Title : Adaptation of local rabies virus isolates to high growth titer to develop vaccine strain in Ethiopia
Abebe Mengesha Aga, Armauer Hansen Research Institute, Ethiopia
Background: Rabies is 100% fatal zoonotic disease with acute encephalitis in humans and animals. The case is most severe in developing countries where cell culture derived anti-rabies vaccines are unaffordable or the available nervous tissue-derived vaccines are of questionable i [....] » Read More
Title : Knowledge and attitude on sexually transmitted infections among widows in Lagos State, Nigeria
Akanle Olanrewaju Basil, University of Lagos, Nigeria
The study examines the knowledge and attitudes of widows towards sexually transmitted infections (STIs) by analyzing the significance of various dependent and independent variables. The analysis reveals several key findings. Firstly, the overall model, as indicated by Pillai&rsqu [....] » Read More
Title : Mathematical modelling on the effects of cultural practices on HIV treatment in luo-nyanza region
Sally Lago, Strathmore University, Kenya
In the intricate tapestry of the fight against HIV, understanding the subtle yet powerful influence of cultural practices is paramount. Traditional practises such as widow cleansing rituals and wife inheritance have been practises that affect HIV transmission and treatment outcom [....] » Read More
Title : Right thalamic abscess in a caucasian man with rheumatoid arthritis, an intriguing case report
Mehwish Zeb, Garden city Hospital, United States
Brain abscess is a localized collection of pus within the brain tissue. It is a rare condition and approximately 1500-2000 cases are presented annually in the United States. The patients with immunocompromised state have a higher incidence of acquiring brain abscess. The most fre [....] » Read More
Title : Syphilitic hepatitis: A rare case of hepatic injury from a commonly transmitted venereal disease
Karthic Drishna Perumal, Mount Carmel Health, United States
Syphilis is a sexually transmitted disease caused by the non-hepatotropic spirochete Treponema pallidum. The disease is typically divided into early (primary and secondary infection) and late (tertiary infection that can be symptomatic or asymptomatic) stages. Syphilitic hepatiti [....] » Read More
Title : PVX_112690 (PvTRAg36.6) - CD71/TFRC interaction study - new insight of plasmodium vivax invasion into human reticulocyte
Manish Tripathi, All India Institute of medical Sciences, India
Aligned with the global objective to eliminate malaria, continuous efforts are made in the field of malaria biology. However, the parasite is similarly advancing itself to be in competition. Our information about parasites is the tip of the iceberg, making this tug of war into th [....] » Read More
Title : Structural deformations in the superior tubular of the hypothalamus and their impact of autoimmune antibody production: A study of long Covid patients
Christof Peter Ziaja, UKE Neuroradiology and Institut of Stress and Fatigue Prof Stark, Germany
Background: Post/Long COVID is a complex multisystemic post-viral syndrome characterized by heterogeneous symptoms, potentially associated with viral or immune-mediated disruption. The superior tubular of the Hypothalamus, responsible for the Immune response and control, plays a [....] » Read More
Title : Transaminitis among patients with dengue fever visiting a tertiary care centre
Sangita Thapa, Medical University of America, Nepal
Introduction: Transaminitis is the condition where serum aspartate transaminase and alanine transaminase increase indicating the liver dysfunction. One such disease where liver involvement might be observed is dengue, which is mosquito-borne viral infection. The aim of the study [....] » Read More
Title : Frequency and associated factors of extra Pulmonary tuberculosis at a tertiary care hospital, Karachi, Pakistan
Hiba Akber, The Indus hospital and Health Network, Pakistan
Introduction: Tuberculosis (TB) is a communicable disease that is a major cause of illness and death worldwide. Risk factors for mortality in patients with Extra pulmonary tuberculosis (EPTB) include certain sites of disease other coexisting conditions, including HIV/AIDS; lo [....] » Read More
Title : Treatment outcomes and associated factors among patients with Drug-Resistant Tuberculosis (DR-TB) at a tertiary government hospital in Nueva Ecija: A seven-year retrospective study
Kelvin Clein M Curitana, Dr. Paulino J. Garcia Memorial Research and Medical Center, Philippines
Drug resistant tuberculosis (DR-TB) poses significant challenges to the control and successful eradication and management of TB worldwide. MDR-TB treatment outcome is the most important indicator in WHO’s End TB strategy. Tracking of treatment outcomes over time is su [....] » Read More
Title : Prospect of achieving a complete vaccination dosage during an outbreak: A secondary analysis of data from a high-frequency phone survey on COVID-19 conducted in Uganda
Akumu Esther Joy, Infectious Diseases Institute, Uganda
Background: Coronavirus disease (COVID-19) was declared a pandemic by the World Health Organization (WHO) on 11th March 2020. COVID-19 vaccination is one of the strategies that was employed to contain COVID-19 infection. In Uganda, COVID-19 vaccination campaigns began in Ma [....] » Read More